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Varicella-zoster Virus

  • Book
  • © 2010

Overview

Editors:
  1. Allison Abendroth

    1. Department of Infectious Diseases and Im, Head, VZV Research Laboratory, University of Sydney, Sydney, Australia

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  2. Ann M. Arvin

    1. School of Medicine, Dept. Microbiology & Immunology, Stanford University, Stanford, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Jennifer F. Moffat

    1. 2215 Weiskotten Hall, Upstate Medical University, Syracuse, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 342)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. The Varicella-Zoster Virus Genome

    • Jeffrey I. Cohen
    Pages 1-14

  3. VZV Molecular Epidemiology

    • Judith Breuer
    Pages 15-42

  4. Roles of Cellular Transcription Factors in VZV Replication

    • William T. Ruyechan
    Pages 43-65

  5. Effects of Varicella-Zoster Virus on Cell Cycle Regulatory Pathways

    • Jennifer F. Moffat, Rebecca J. Greenblatt
    Pages 67-77

  6. Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase and Its Relationship to Alphaherpesvirus US3 Kinases

    • Angela Erazo, Paul R. Kinchington
    Pages 79-98

  7. VZV ORF47 Serine Protein Kinase and Its Viral Substrates

    • Teri K. Kenyon, Charles Grose
    Pages 99-111

  8. Overview of Varicella-Zoster Virus Glycoproteins gC, gH and gL

    • Charles Grose, John E. Carpenter, Wallen Jackson, Karen M. Duus
    Pages 113-128

  9. Analysis of the Functions of Glycoproteins E and I and Their Promoters During VZV Replication In Vitro and in Skin and T-Cell Xenografts in the SCID Mouse Model of VZV Pathogenesis

    • Ann M. Arvin, Stefan Oliver, Mike Reichelt, Jennifer F. Moffat, Marvin Sommer, Leigh Zerboni et al.
    Pages 129-146

  10. Varicella-Zoster Virus Glycoprotein M

    • Yasuko Mori, Tomohiko Sadaoka
    Pages 147-154

  11. Varicella Zoster Virus Immune Evasion Strategies

    • Allison Abendroth, Paul R. Kinchington, Barry Slobedman
    Pages 155-171

  12. VZV Infection of Keratinocytes: Production of Cell-Free Infectious Virions In Vivo

    • Michael D. Gershon, Anne A. Gershon
    Pages 173-188

  13. Varicella-Zoster Virus T Cell Tropism and the Pathogenesis of Skin Infection

    • Ann M. Arvin, Jennifer F. Moffat, Marvin Sommer, Stefan Oliver, Xibing Che, Susan Vleck et al.
    Pages 189-209

  14. Experimental Models to Study Varicella-Zoster Virus Infection of Neurons

    • Megan Steain, Barry Slobedman, Allison Abendroth
    Pages 211-228

  15. Molecular Characterization of Varicella Zoster Virus in Latently Infected Human Ganglia: Physical State and Abundance of VZV DNA, Quantitation of Viral Transcripts and Detection of VZV-Specific Proteins

    • Yevgeniy Azarkh, Don Gilden, Randall J. Cohrs
    Pages 229-241

  16. Neurological Disease Produced by Varicella Zoster Virus Reactivation Without Rash

    • Don Gilden, Randall J. Cohrs, Ravi Mahalingam, Maria A. Nagel
    Pages 243-253

  17. Varicella-Zoster Virus Neurotropism in SCID Mouse–Human Dorsal Root Ganglia Xenografts

    • L. Zerboni, M. Reichelt, A. Arvin
    Pages 255-276

  18. Rodent Models of Varicella-Zoster Virus Neurotropism

    • Jeffrey I. Cohen
    Pages 277-289

  19. Simian Varicella Virus: Molecular Virology

    • Wayne L. Gray
    Pages 291-308

  20. Simian Varicella Virus Pathogenesis

    • Ravi Mahalingam, Ilhem Messaoudi, Don Gilden
    Pages 309-321
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Keywords

About this book

Varicella-zoster virus is a common human pathogen that causes varicella (chickenpox), establishes latency in sensory nerve ganglia and can reactivate many years later as herpes zoster. Although the VZV genome is the smallest of the human herpesviruses, VZV genes encode at least 70 proteins. Molecular epidemiologic approaches based on genomic sequencing have documented the global distribution of VZV in distinct clades that reflect patterns of human migration. Contemporary molecular methods are making it possible to dissect how VZV gene products support the viral life cycle, including those that are necessary for viral replication, virion assembly and egress as well as those that permit take over of the host cell by modulating cell cycle regulation, survival and intrinsic antiviral responses. Progress is also being made in understanding the events in VZV pathogenesis and the viral tropisms for keratinocytes, T cells, dendritic cells and neurons during primary infection, latency and reactivation and the innate and adaptive host responses that modulate these events. New insights about molecular virology and pathogenesis have emerged from comparative studies of VZV and simian varicella virus. VZV is the only human herpesvirus for which vaccines to prevent both primary and recurrent infection are approved and VZV vaccines have had significant public health benefits. These achievements and new directions that are unfolding are described in this review of VZV basic and clinical research

Editors and Affiliations

  • Department of Infectious Diseases and Im, Head, VZV Research Laboratory, University of Sydney, Sydney, Australia

    Allison Abendroth

  • School of Medicine, Dept. Microbiology & Immunology, Stanford University, Stanford, USA

    Ann M. Arvin

  • 2215 Weiskotten Hall, Upstate Medical University, Syracuse, USA

    Jennifer F. Moffat

Bibliographic Information

  • Book Title: Varicella-zoster Virus

  • Editors: Allison Abendroth, Ann M. Arvin, Jennifer F. Moffat

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-12728-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2010

  • Hardcover ISBN: 978-3-642-12727-4Published: 30 August 2010

  • Softcover ISBN: 978-3-642-26466-5Published: 13 October 2012

  • eBook ISBN: 978-3-642-12728-1Published: 30 September 2010

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIV, 378

  • Topics: Virology

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