Current Topics in Microbiology and Immunology

Varicella-zoster Virus

Editors: Abendroth, Allison, Arvin, Ann M., Moffat, Jennifer F. (Eds.)

  • Reviews basic and clinical research on Varicella-zoster Virus
  • Covers the only human herpesvirus approved vaccines to prevent both primary and recurrent infection
  • Describes the significant public health benefits of VZV vaccination
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eBook $229.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-642-12728-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-642-12727-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-642-26466-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Varicella-zoster virus is a common human pathogen that causes varicella (chickenpox), establishes latency in sensory nerve ganglia and can reactivate many years later as herpes zoster. Although the VZV genome is the smallest of the human herpesviruses, VZV genes encode at least 70 proteins. Molecular epidemiologic approaches based on genomic sequencing have documented the global distribution of VZV in distinct clades that reflect patterns of human migration. Contemporary molecular methods are making it possible to dissect how VZV gene products support the viral life cycle, including those that are necessary for viral replication, virion assembly and egress as well as those that permit take over of the host cell by modulating cell cycle regulation, survival and intrinsic antiviral responses. Progress is also being made in understanding the events in VZV pathogenesis and the viral tropisms for keratinocytes, T cells, dendritic cells and neurons during primary infection, latency and reactivation and the innate and adaptive host responses that modulate these events. New insights about molecular virology and pathogenesis have emerged from comparative studies of VZV and simian varicella virus. VZV is the only human herpesvirus for which vaccines to prevent both primary and recurrent infection are approved and VZV vaccines have had significant public health benefits. These achievements and new directions that are unfolding are described in this review of VZV basic and clinical research

Table of contents (22 chapters)

  • The Varicella-Zoster Virus Genome

    Cohen, Jeffrey I.

    Pages 1-14

  • VZV Molecular Epidemiology

    Breuer, Judith

    Pages 15-42

  • Roles of Cellular Transcription Factors in VZV Replication

    Ruyechan, William T.

    Pages 43-65

  • Effects of Varicella-Zoster Virus on Cell Cycle Regulatory Pathways

    Moffat, Jennifer F. (et al.)

    Pages 67-77

  • Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase and Its Relationship to Alphaherpesvirus US3 Kinases

    Erazo, Angela (et al.)

    Pages 79-98

Buy this book

eBook $229.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-642-12728-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-642-12727-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-642-26466-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Varicella-zoster Virus
Editors
  • Allison Abendroth
  • Ann M. Arvin
  • Jennifer F. Moffat
Series Title
Current Topics in Microbiology and Immunology
Series Volume
342
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-12728-1
DOI
10.1007/978-3-642-12728-1
Hardcover ISBN
978-3-642-12727-4
Softcover ISBN
978-3-642-26466-5
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIV, 378
Topics