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Toxic Plant Proteins

  • Book
  • © 2010

Overview

Editors:
  1. J. Michael Lord

    1. Dept. Biological Sciences, University of Warwick, Coventry, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Martin R. Hartley

    1. Dept. Biological Sciences, University of Warwick, Coventry, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Written by acknowledged experts in the field
  • the book focuses on the structure, function and some
  • potential applications of toxic plant proteins

Part of the book series: Plant Cell Monographs (CELLMONO, volume 18)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-x
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  2. Evolution of Plant Ribosome-Inactivating Proteins

    • Willy J. Peumans, Els J. M. Van Damme
    Pages 1-26

  3. RNA N-Glycosidase Activity of Ribosome-Inactivating Proteins

    • Kazuyuki Takai, Tatsuya Sawasaki, Yaeta Endo
    Pages 27-39

  4. Enzymatic Activities of Ribosome-Inactivating Proteins

    • Martin R. Hartley
    Pages 41-54

  5. Type I Ribosome-Inactivating Proteins from Saponaria officinalis

    • Alessio Lombardi, Richard S. Marshall, Carmelinda Savino, Maria Serena Fabbrini, Aldo Ceriotti
    Pages 55-78

  6. Type 1 Ribosome-Inactivating Proteins from the Ombú Tree (Phytolacca dioica L.)

    • Augusto Parente, Rita Berisio, Angela Chambery, Antimo Di Maro
    Pages 79-106

  7. Sambucus Ribosome-Inactivating Proteins and Lectins

    • José Miguel Ferreras, Lucía Citores, Rosario Iglesias, Pilar Jiménez, Tomás Girbés
    Pages 107-131

  8. Ribosome-Inactivating Proteins from Abrus pulchellus

    • Ana Paula Ulian Araújo, Priscila Vasques Castilho, Leandro Seiji Goto
    Pages 133-147

  9. Ribosome-Inactivating Proteins in Cereals

    • Carlotta Balconi, Chiara Lanzanova, Mario Motto
    Pages 149-166

  10. Ribosome Inactivating Proteins and Apoptosis

    • Deepa Sikriwal, Janendra K. Batra
    Pages 167-189

  11. The Synthesis of Ricinus communis Lectins

    • Lorenzo Frigerio, Lynne M. Roberts
    Pages 191-205

  12. How Ricin Reaches its Target in the Cytosol of Mammalian Cells

    • Robert A. Spooner, Jonathan P. Cook, Shuyu Li, Paula Pietroni, J. Michael Lord
    Pages 207-224

  13. Ribosome-Inactivating Protein-Containing Conjugates for Therapeutic Use

    • Giulio Fracasso, Fiorenzo Stirpe, Marco Colombatti
    Pages 225-263

  14. Back Matter

    Pages 265-270
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Keywords

About this book

Many plants produce enzymes collectively known as ribosome-inactivating proteins (RIPs). RIPs catalyze the removal of an adenine residue from a conserved loop in the large ribosomal RNA. The adenine residue removed by this depurination is crucial for the binding of elongation factors. Ribosomes modified in this way are no longer able to carry out protein synthesis. Most RIPs exist as single polypeptides (Type 1 RIPs) which are largely non-toxic to mammalian cells because they are unable to enter them and thus cannot reach their ribosomal substrate. In some instances, however, the RIP forms part of a heterodimer where its partner polypeptide is a lectin (Type 2 RIPs). These heterodimeric RIPs are able to bind to and enter mammalian cells. Their ability to reach and modify ribosomes in target cells means these proteins are some of the most potently cytotoxic poisons found in nature, and are widely assumed to play a protective role as part of the host plant’s defenses. RIPs are able to further damage target cells by inducing apoptosis. In addition, certain plants produce lectins lacking an RIP component but which are also cytotoxic. This book focuses on the structure/function and some potential applications of these toxic plant proteins.

Editors and Affiliations

  • Dept. Biological Sciences, University of Warwick, Coventry, United Kingdom

    J. Michael Lord, Martin R. Hartley

Bibliographic Information

  • Book Title: Toxic Plant Proteins

  • Editors: J. Michael Lord, Martin R. Hartley

  • Series Title: Plant Cell Monographs

  • DOI: https://doi.org/10.1007/978-3-642-12176-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2010

  • Hardcover ISBN: 978-3-642-12175-3Published: 17 June 2010

  • Softcover ISBN: 978-3-642-26377-4Published: 05 September 2012

  • eBook ISBN: 978-3-642-12176-0Published: 20 July 2010

  • Series ISSN: 1861-1370

  • Series E-ISSN: 1861-1362

  • Edition Number: 1

  • Number of Pages: X, 270

  • Number of Illustrations: 29 b/w illustrations, 12 illustrations in colour

  • Topics: Plant Biochemistry, Cell Biology, Plant Physiology, Plant Sciences

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