Plant Cell Monographs

Toxic Plant Proteins

Editors: Lord, J. Michael, Hartley, Martin R. (Eds.)

  • Written by acknowledged experts in the field
  • the book focuses on the structure, function and some
  • potential applications of toxic plant proteins
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eBook $229.00
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  • ISBN 978-3-642-12176-0
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Hardcover $299.00
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  • ISBN 978-3-642-12175-3
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Softcover $299.00
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  • ISBN 978-3-642-26377-4
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About this book

Many plants produce enzymes collectively known as ribosome-inactivating proteins (RIPs). RIPs catalyze the removal of an adenine residue from a conserved loop in the large ribosomal RNA. The adenine residue removed by this depurination is crucial for the binding of elongation factors. Ribosomes modified in this way are no longer able to carry out protein synthesis. Most RIPs exist as single polypeptides (Type 1 RIPs) which are largely non-toxic to mammalian cells because they are unable to enter them and thus cannot reach their ribosomal substrate. In some instances, however, the RIP forms part of a heterodimer where its partner polypeptide is a lectin (Type 2 RIPs). These heterodimeric RIPs are able to bind to and enter mammalian cells. Their ability to reach and modify ribosomes in target cells means these proteins are some of the most potently cytotoxic poisons found in nature, and are widely assumed to play a protective role as part of the host plant’s defenses. RIPs are able to further damage target cells by inducing apoptosis. In addition, certain plants produce lectins lacking an RIP component but which are also cytotoxic. This book focuses on the structure/function and some potential applications of these toxic plant proteins.

Table of contents (12 chapters)

  • Evolution of Plant Ribosome-Inactivating Proteins

    Peumans, Willy J. (et al.)

    Pages 1-26

  • RNA N-Glycosidase Activity of Ribosome-Inactivating Proteins

    Takai, Kazuyuki (et al.)

    Pages 27-39

  • Enzymatic Activities of Ribosome-Inactivating Proteins

    Hartley, Martin R.

    Pages 41-54

  • Type I Ribosome-Inactivating Proteins from Saponaria officinalis

    Lombardi, Alessio (et al.)

    Pages 55-78

  • Type 1 Ribosome-Inactivating Proteins from the Ombú Tree (Phytolacca dioica L.)

    Parente, Augusto (et al.)

    Pages 79-106

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-642-12176-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.00
price for USA
  • ISBN 978-3-642-12175-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $299.00
price for USA
  • ISBN 978-3-642-26377-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Toxic Plant Proteins
Editors
  • J. Michael Lord
  • Martin R. Hartley
Series Title
Plant Cell Monographs
Series Volume
18
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-12176-0
DOI
10.1007/978-3-642-12176-0
Hardcover ISBN
978-3-642-12175-3
Softcover ISBN
978-3-642-26377-4
Series ISSN
1861-1370
Edition Number
1
Number of Pages
X, 270
Number of Illustrations and Tables
29 b/w illustrations, 12 illustrations in colour
Topics