Research and Perspectives in Endocrine Interactions

IGFs:Local Repair and Survival Factors Throughout Life Span

Editors: Clemmons, David, Robinson, Iain C.A.F. (Eds.)

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About this book

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

Table of contents (11 chapters)

  • GH & IGF1: Aspects of Global and Local Release and Actions

    Robinson, Iain C. A. F.

    Pages 1-10

  • Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation

    Clemmons, David R. (et al.)

    Pages 11-20

  • IGFBP2 Supports ex vivo Expansion of Hematopoietic Stem Cells

    Huynh, HoangDinh (et al.)

    Pages 21-41

  • The Role of Insulin-like Growth Factor-I in Central Nervous System Development

    D’Ercole, A. Joseph (et al.)

    Pages 43-58

  • Stimulation of Proliferative Pathways by IGF-binding Proteins

    Baxter, Robert C. (et al.)

    Pages 59-68

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-3-642-04302-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-3-642-04301-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
IGFs:Local Repair and Survival Factors Throughout Life Span
Editors
  • David Clemmons
  • Iain C.A.F. Robinson
Series Title
Research and Perspectives in Endocrine Interactions
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-04302-4
DOI
10.1007/978-3-642-04302-4
Hardcover ISBN
978-3-642-04301-7
Series ISSN
1861-2253
Edition Number
1
Number of Pages
XIII, 157
Topics