Research and Perspectives in Alzheimer's Disease

Diabetes, Insulin and Alzheimer's Disease

Editors: Craft, Suzanne (Ed.)

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About this book

Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet’s evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin’s involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer’s disease.

This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects.

Table of contents (12 chapters)

  • Insulin Action in the Brain and the Pathogenesis of Alzheimer’s Disease

    Kahn, C. Ronald (et al.)

    Pages 1-20

  • The Brain-insulin Connection, Metabolic Diseases and Related Pathologies

    Gerozissis, Kyriaki

    Pages 21-42

  • Insulin-Mediated Neuroplasticity in the Central Nervous System

    Reagan, Lawrence P.

    Pages 43-56

  • Stress Hormones and Neuroplasticity in the Diabetic Brain

    Stranahan, Alexis M. (et al.)

    Pages 57-71

  • Diabetes and the Brain – An Epidemiologic Perspective

    Launer, Lenore J.

    Pages 73-80

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-642-04300-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-642-04299-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-26281-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Diabetes, Insulin and Alzheimer's Disease
Editors
  • Suzanne Craft
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-04300-0
DOI
10.1007/978-3-642-04300-0
Hardcover ISBN
978-3-642-04299-7
Softcover ISBN
978-3-642-26281-4
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XIV, 218
Number of Illustrations and Tables
9 b/w illustrations, 21 illustrations in colour
Topics