Research and Perspectives in Neurosciences

Macro Roles for MicroRNAs in the Life and Death of Neurons

Editors: De Strooper, Bart (Ed.)

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-642-04298-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-642-04297-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-642-26204-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we have gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. These novel insights appear to be particular promising for the understanding of the very frequent and badly understood sporadic forms of these diseases as compared to the genetic forms. Thus, the better understanding of the implications of this novel field of molecular biology is crucial for the broad area of neurosciences, from the fundamental aspects to the clinic, and from novel diagnostic to potentially therapeutic applications for severe neurological and maybe psychiatric diseases.

Table of contents (11 chapters)

  • Profiling the microRNAs

    Kosik, Kenneth S. (et al.)

    Pages 1-8

  • The Wide Variety of miRNA Expression Profiles in the Developing and Mature CNS

    Kapsimali, Marika

    Pages 9-17

  • Interactions between microRNAs and Transcription Factors in the Development and Function of the Nervous System

    Simon, David J.

    Pages 19-26

  • A microRNA Feedback Circuit in Midbrain Dopamine Neurons

    Abeliovich, Asa

    Pages 27-33

  • Fine-tuning mRNA Translation at Synapses with microRNAs

    Schratt, Gerhard M.

    Pages 35-44

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-642-04298-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-642-04297-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-642-26204-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Macro Roles for MicroRNAs in the Life and Death of Neurons
Editors
  • Bart De Strooper
Series Title
Research and Perspectives in Neurosciences
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-04298-0
DOI
10.1007/978-3-642-04298-0
Hardcover ISBN
978-3-642-04297-3
Softcover ISBN
978-3-642-26204-3
Series ISSN
0945-6082
Edition Number
1
Number of Pages
XII, 121
Number of Illustrations and Tables
16 illustrations in colour
Topics