Progress in Molecular and Subcellular Biology

miRNA Regulation of the Translational Machinery

Editors: Rhoads, Robert (Ed.)

  • Up-to-date findings on influence of miRNAs on gene translation
  • Gives an overview on different microRNA types and functions in plants and animals
  • Shows novel applications of microRNAs
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About this book

The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).

Table of contents (7 chapters)

  • Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression

    Fabian, Marc R. (et al.)

    Pages 1-20

  • Translational Control of Endogenous MicroRNA Target Genes in C. elegans

    Hurschler, Benjamin A. (et al.)

    Pages 21-40

  • Translational Inhibition by MicroRNAs in Plants

    Yu, Bin (et al.)

    Pages 41-57

  • Regulation of p27kip1 mRNA Expression by MicroRNAs

    Martínez-Sánchez, Aida (et al.)

    Pages 59-70

  • The Inhibitory Effect of Apolipoprotein B mRNA-Editing Enzyme Catalytic Polypeptide-Like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs

    Zhang, Hui

    Pages 71-83

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-642-03103-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-642-03102-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-642-26140-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
miRNA Regulation of the Translational Machinery
Editors
  • Robert Rhoads
Series Title
Progress in Molecular and Subcellular Biology
Series Volume
50
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-03103-8
DOI
10.1007/978-3-642-03103-8
Hardcover ISBN
978-3-642-03102-1
Softcover ISBN
978-3-642-26140-4
Series ISSN
0079-6484
Edition Number
1
Number of Pages
X, 115
Number of Illustrations and Tables
19 b/w illustrations, 4 illustrations in colour
Topics