Results and Problems in Cell Differentiation

Death Receptors and Cognate Ligands in Cancer

Editors: Kalthoff, Holger (Ed.)

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  • ISBN 978-3-642-03045-1
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About this book

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events.

Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells.

This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

Table of contents (12 chapters)

  • The Role of TNF in Cancer

    Wajant, Harald

    Pages 1-15

  • Many Checkpoints on the Road to Cell Death:Regulation of Fas–FasL Interactions and Fas Signaling in Peripheral Immune Responses

    Ramaswamy, Madhu (et al.)

    Pages 17-47

  • FasL Expression and Reverse Signalling

    Lettau, M. (et al.)

    Pages 49-61

  • Impact of TNF-R1 and CD95 Internalization on Apoptotic and Antiapoptotic Signaling

    Schütze, Stefan (et al.)

    Pages 63-85

  • Ubiquitination and TNFR1 Signaling

    Fujita, Ken-ichi (et al.)

    Pages 87-114

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-642-03045-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.00
price for USA
  • ISBN 978-3-642-03044-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $299.00
price for USA
  • ISBN 978-3-642-26076-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Death Receptors and Cognate Ligands in Cancer
Editors
  • Holger Kalthoff
Series Title
Results and Problems in Cell Differentiation
Series Volume
49
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-03045-1
DOI
10.1007/978-3-642-03045-1
Hardcover ISBN
978-3-642-03044-4
Softcover ISBN
978-3-642-26076-6
Series ISSN
0080-1844
Edition Number
1
Number of Pages
XIV, 280
Number of Illustrations and Tables
11 b/w illustrations, 9 illustrations in colour
Topics