Handbook of Experimental Pharmacology

Adverse Drug Reactions

Editors: Uetrecht, Jack (Ed.)

  • Provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs)
  • Main focus is on idiosyncratic drug reactions
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  • ISBN 978-3-642-00663-0
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About this book

This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.

Table of contents (19 chapters)

  • Drug-Induced Liver Injury

    Holt, Michael (et al.)

    Pages 3-27

  • Drug Hypersensitivity Reactions Involving Skin

    Hausmann, Oliver (et al.)

    Pages 29-55

  • Adverse Drug Reactions Affecting Blood Cells

    Aster, Richard H.

    Pages 57-76

  • Molecular Mechanisms of Adverse Drug Reactions in Cardiac Tissue

    Tabrizchi, Reza

    Pages 77-109

  • Mechanisms of Drug-Induced Nephrotoxicity

    Nolin, Thomas D. (et al.)

    Pages 111-130

Buy this book

eBook $359.00
price for USA (gross)
  • ISBN 978-3-642-00663-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Adverse Drug Reactions
Editors
  • Jack Uetrecht
Series Title
Handbook of Experimental Pharmacology
Series Volume
196
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-00663-0
DOI
10.1007/978-3-642-00663-0
Series ISSN
0171-2004
Edition Number
1
Number of Pages
X, 556
Number of Illustrations and Tables
4 illustrations in colour
Topics