Advances in Anatomy, Embryology and Cell Biology

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

Authors: David, J., Middendorff, R., Müller, D., Holstein, A.F.

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About this book

The Leydig cells of the testis represent the main source of androgens. The idea of Leydig cells as endocrine cells has been the leading characteristic of this interesting cell population till now. Our studies of the last 2 decades allowed us to reveal a new important feature of Leydig cells that is their obvious similarity with structures of the central and peripheral nervous system. This includes the expression of neurohormones, neurotransmitters, neuropeptides and glial cell antigens. In this way, it became evident that in addition to the well established control by steroids and systemic hormones, important local auto- and paracrine control mechanisms of testicular functions exist.

Thus, the Leydig cells represent a specialized cell population with both endocrine and neuroendocrine properties. The discovery of the neuroendocrine features of Leydig cells gave rise to the hypothesis of a potential neuroectodermal and/or neural crest origin of testicular Leydig cells. In an experimental animal model we revealed that adult Leydig cells originate by transdifferentiation from stem/progenitor cells (pericytes and smooth muscle cells), underlying the close relationship of Leydig cells with testis microvasculature. This and the supporting data from the literature provided the basis for revealing the pericytes as a common adult stem cell type of mammalian species. Distributed by the microvasculature through the entire body, the pericyte, acting as a resting early pluripotent adult stem cell, provides an ingenious system to assure the maintenance, physiological repair and regeneration of organs, each under the influence of specific local environmental factors.

Table of contents (9 chapters)

  • Introduction

    Davidoff, Michail S. (et al.)

    Pages 1-2

  • History of and Recent Progress in Leydig Cell Research

    Davidoff, Michail S. (et al.)

    Pages 3-8

  • Morphology of the Leydig Cells

    Davidoff, Michail S. (et al.)

    Pages 9-18

  • The Well-Known Endocrine Function of the Leydig Cells

    Davidoff, Michail S. (et al.)

    Pages 19-21

  • The Neuroendocrine Properties of the Leydig Cells

    Davidoff, Michail S. (et al.)

    Pages 23-43

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-642-00513-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $259.00
price for USA
  • ISBN 978-3-642-00512-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes
Authors
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
205
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-00513-8
DOI
10.1007/978-3-642-00513-8
Softcover ISBN
978-3-642-00512-1
Series ISSN
0301-5556
Edition Number
1
Number of Pages
X, 154
Number of Illustrations and Tables
20 b/w illustrations, 2 illustrations in colour
Topics