Current Topics in Microbiology and Immunology

Autophagy in Infection and Immunity

Editors: Levine, Beth, Yoshimori, Tamotsu, Deretic, Vojo (Eds.)

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  • ISBN 978-3-642-00302-8
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About this book

Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy’s ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy’s roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes central tolerance; it affects B and T cell homeostasis; it acts both as an effector and a regulator of Toll-like receptor and other innate immunity receptor signaling; and it may help ward off chronic inflammatory disease in humans. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.

Table of contents (16 chapters)

  • An Overview of the Molecular Mechanism of Autophagy

    Yang, Zhifen (et al.)

    Pages 1-32

  • Macroautophagy Signaling and Regulation

    Esclatine, Audrey (et al.)

    Pages 33-70

  • Physiological Functions of Autophagy

    Mizushima, Noboru

    Pages 71-84

  • Autophagy and Lymphocyte Homeostasis

    Pua, Heather H. (et al.)

    Pages 85-105

  • Autophagy and Innate Recognition Systems

    Tal, Michal Caspi (et al.)

    Pages 107-121

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-642-00302-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-642-00301-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-3-642-26037-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Autophagy in Infection and Immunity
Editors
  • Beth Levine
  • Tamotsu Yoshimori
  • Vojo Deretic
Series Title
Current Topics in Microbiology and Immunology
Series Volume
335
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-00302-8
DOI
10.1007/978-3-642-00302-8
Hardcover ISBN
978-3-642-00301-1
Softcover ISBN
978-3-642-26037-7
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIV, 339
Number of Illustrations and Tables
15 b/w illustrations, 35 illustrations in colour
Topics