Research and Perspectives in Alzheimer's Disease

Intracellular Traffic and Neurodegenerative Disorders

Editors: St.George-Hyslop, Peter H., Mobley, William C. (Eds.)

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About this book

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.

Reviews

From the reviews:

“This monograph is an up to date account of the abnormalities in axonal transport of proteins and molecules in neurons in the aging and diseased brain. … This book is meant for neuropathologists, neurologists, and advanced graduate students in the Neurosciences. I can recommend it for these professionals without hesitation.” (Joseph J. Grenier, Amazon.com, November, 2013)

Table of contents (13 chapters)

  • Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms

    Gandy, Sam (et al.)

    Pages 1-9

  • Intramembrane Proteolysis by γ-Secretase and Signal Peptide Peptidases

    Fluhrer, Regina (et al.)

    Pages 11-26

  • Axonal Transport and Neurodegenerative Disease

    Holzbaur, Erika L. F.

    Pages 27-39

  • Simple Cellular Solutions to Complex Problems

    Lindquist, Susan (et al.)

    Pages 41-57

  • Tau and Intracellular Transport in Neurons

    Mandelkow, E.-M. (et al.)

    Pages 59-70

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-3-540-87941-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-3-540-87940-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-3-642-09972-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Intracellular Traffic and Neurodegenerative Disorders
Editors
  • Peter H. St.George-Hyslop
  • William C. Mobley
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-87941-1
DOI
10.1007/978-3-540-87941-1
Hardcover ISBN
978-3-540-87940-4
Softcover ISBN
978-3-642-09972-4
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XIV, 184
Number of Illustrations and Tables
11 b/w illustrations, 25 illustrations in colour
Topics