Ernst Schering Foundation Symposium Proceedings

Oncogenes Meet Metabolism

From Deregulated Genes to a Broader Understanding of Tumour Physiology

Editors: Kroemer, G., Mumberg, D., Keun, K., Riefke, B., Steger-Hartmann, Th., Petersen, K. (Eds.)

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  • ISBN 978-3-540-79478-3
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About this book

In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

Table of contents (12 chapters)

  • Mitochondria and Cancer

    Rustin, P. (et al.)

    Pages 1-21

  • Role of the Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression

    White, E.

    Pages 23-34

  • The Interplay Between MYC and HIF in the Warburg Effect

    Dang, C. V.

    Pages 35-53

  • Using Metabolomics to Monitor Anticancer Drugs

    Chung, Y.-L. (et al.)

    Pages 55-78

  • Biomarker Discovery for Drug Development and Translational Medicine Using Metabonomics

    Keun, H. C.

    Pages 79-98

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-3-540-79478-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-3-540-79477-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-3-642-09840-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Oncogenes Meet Metabolism
Book Subtitle
From Deregulated Genes to a Broader Understanding of Tumour Physiology
Editors
  • Guido Kroemer
  • Dominik Mumberg
  • Kector Keun
  • Björn Riefke
  • Thomas Steger-Hartmann
  • Kirstin Petersen
Series Title
Ernst Schering Foundation Symposium Proceedings
Series Volume
2007/4
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-79478-3
DOI
10.1007/978-3-540-79478-3
Hardcover ISBN
978-3-540-79477-6
Softcover ISBN
978-3-642-09840-6
Series ISSN
0947-6075
Edition Number
1
Number of Pages
XV, 265
Topics