Current Topics in Microbiology and Immunology

Humanized Mice

Editors: Nomura, Tatsuji, Watanabe, Takeshi, Habu, Sonoko (Eds.)

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-540-75647-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-540-75646-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-42077-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.

Table of contents (12 chapters)

  • Basic Concept of Development and Practical Application of Animal Models for Human Diseases

    Nomura, Tatsuji (et al.)

    Pages 1-24

  • Humanized SCID Mouse Models for Biomedical Research

    Pearson, T. (et al.)

    Pages 25-51

  • NOD/Shi-scid IL2rγnull (NOG) Mice More Appropriate for Humanized Mouse Models

    Ito, M. (et al.)

    Pages 53-76

  • Humanizing Bone Marrow in Immune-Deficient Mice

    Ando, K. (et al.)

    Pages 77-86

  • The Differentiative and Regenerative Properties of Human Hematopoietic Stem/Progenitor cells in NOD-SCID/IL2rγnull Mice

    Ishikawa, F. (et al.)

    Pages 87-94

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-540-75647-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-540-75646-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-42077-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Humanized Mice
Editors
  • Tatsuji Nomura
  • Takeshi Watanabe
  • Sonoko Habu
Series Title
Current Topics in Microbiology and Immunology
Series Volume
324
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-75647-7
DOI
10.1007/978-3-540-75647-7
Hardcover ISBN
978-3-540-75646-0
Softcover ISBN
978-3-642-42077-1
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIII, 199
Topics