Genome Dynamics and Stability

Recombination and Meiosis

Crossing-Over and Disjunction

Editors: Egel, Richard, Lankenau, Dirk (Eds.)

  • First book to give a detailed insight in the processes and mechanisms taking place in the cell during meiosis and recombination
  • Written by high-impact authors from the field
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eBook $289.00
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  • ISBN 978-3-540-75373-5
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Hardcover $369.00
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About this book

Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II – reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Central to mainstream meiosis, the mechanisms of reciprocal exchange at crossover/chiasma sites stand out as a controlled program of biologically significant molecular changes. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that is subsequently repaired by homologous recombination. These key events are accompanied by ancillary provisions at the level of chromosome core organization, sister chromatid cohesion, and differential centromere connectivity. Great progress has been made in recent years to further our understanding of these mechanisms. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Arabidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume.

Table of contents (10 chapters)

  • Meiotic Crossing-Over and Disjunction: Overt and Hidden Layers of Description and Control

    Egel, Richard

    Pages 1-30

  • Chromatid Cores in Meiotic Chromosome Structure and Segregation

    Suja, José A. (et al.)

    Pages 31-56

  • Sister Chromatid Cohesion and Centromere Organization in Meiosis

    Tanaka, Koichi (et al.)

    Pages 57-79

  • Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis

    Keeney, Scott

    Pages 81-123

  • Synapsis, Double-Strand Breaks, and Domains of Crossover Control in Drosophila Females

    Mehrotra, Sonam (et al.)

    Pages 125-151

Buy this book

eBook $289.00
price for USA (gross)
  • ISBN 978-3-540-75373-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $369.00
price for USA
  • ISBN 978-3-540-75371-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $369.00
price for USA
  • ISBN 978-3-642-09459-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Recombination and Meiosis
Book Subtitle
Crossing-Over and Disjunction
Editors
  • Richard Egel
  • Dirk Lankenau
Series Title
Genome Dynamics and Stability
Series Volume
2
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-75373-5
DOI
10.1007/978-3-540-75373-5
Hardcover ISBN
978-3-540-75371-1
Softcover ISBN
978-3-642-09459-0
Series ISSN
1861-3373
Edition Number
1
Number of Pages
XV, 365
Topics