Research and Perspectives in Neurosciences

Retrotransposition, Diversity and the Brain

Editors: Gage, Fred H. (Ed.)

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About this book

Retroelements are ancient mobile DNA found in most organisms. Long dismissed as useless, selfish or "junk" DNA, they were thought to be mere intracellular parasites from our distant evolutionary past. Together with their mutant relatives, L1 sequences constitute almost 50% of the mammalian genome. L1s can retrotranspose in a defined window of the neuronal differentiation, changing the genetic information in single neurons in a "random" fashion, allowing the brain to develop in distinct different ways. Such strategy contributes to expand the number of functionally distinct neurons that could be produced from a given stem cell gene pool. This characteristic of variety and flexibility may contribute to the uniqueness of an individual brain, even between genetically identical twins. These mobile elements may be part of conserved core process responsible for evoking facilitated complex non-random phenotypical variation on which selection may act. A detailed understanding of the basic mechanisms of L1 activity may shed light on one possible mechanism for generating neural diversity.

The book results from a fascinating and stimulating exchange of ideas at the interface of the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. This meeting of leading geneticists, molecular biologists and neuroscientists was organized by the Fondation IPSEN. Its ambitious goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases. The reader can judge how far the book achieves this.

Table of contents (9 chapters)

  • Telomeres and Telomerase in Human Health and Disease

    Lin, Jue (et al.)

    Pages 1-12

  • Molecular and Circuit Mechanisms for Hippocampal Learning

    Tonegawa, Susumu (et al.)

    Pages 13-19

  • Retrotransposons – Natural and Synthetic

    Boeke, Jef D. (et al.)

    Pages 21-32

  • Ancient Retrotransposons as Possible Remnants of the Primitive RNPWorld

    Ivanyi-Nagy, Roland (et al.)

    Pages 33-42

  • Human Diversity and L1 Retrotransposon Biology: Creation of New Genes and Individual Variation in Retrotransposition Potential

    Kazazian, H.H. (et al.)

    Pages 43-52

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-3-540-74966-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-3-540-74965-3
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $169.00
price for USA
  • ISBN 978-3-642-09437-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Retrotransposition, Diversity and the Brain
Editors
  • Fred H. Gage
Series Title
Research and Perspectives in Neurosciences
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-74966-0
DOI
10.1007/978-3-540-74966-0
Hardcover ISBN
978-3-540-74965-3
Softcover ISBN
978-3-642-09437-8
Series ISSN
0945-6082
Edition Number
1
Number of Pages
XII, 123
Topics