Overview
- Editors:
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Fred H. Gage
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Yves Christen
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Table of contents (9 papers)
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- Jue Lin, Elissa S. Epel, Elizabeth H. Blackburn
Pages 1-12
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- Susumu Tonegawa, Thomas J. McHugh
Pages 13-19
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- Jef D. Boeke, Wenfeng An, Lixin Dai, Edward S. Davis, Jeffrey S. Han, Kathryn A. O’Donnell et al.
Pages 21-32
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- Roland Ivanyi-Nagy, Jean-Luc Darlix
Pages 33-42
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- H.H. Kazazian, M.d.C Seleme, D.V Babusho, D.M. Ostertag, M.R. Vetter, P.K. Mandal
Pages 43-52
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- Alysson R. Muotri, Maria C.N. Marchetto, Fred H. Gage
Pages 53-64
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- Robert H. Yolken, Håkan Karlsson, Ioannis Bossis, Linnéa Asp, Faith Dickerson, Christoffer Nellåker et al.
Pages 65-85
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- T.J. Crow, J.S. Close, H.-S. Kim, M.T. Ross
Pages 87-108
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- Edward C. Gilmore, Christopher A. Walsh
Pages 109-120
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Back Matter
Pages 121-123
About this book
The human brain is remarkably complex, permitting sophisticated behavioural rep- toires, such as languages, tool use, self-awareness, symbolic thought, cultural learning and consciousness. Each human being is different, due in part to the uniqueness of the neuronal heterogeneity and interconnections in our brains. Brain complexity and neuronal diversity are strongly related. The diversity of single neurons provides the underpinnings for how neuronal circuits operate. How and when neuronal diversity is generated, both in embryonic and adult neurogenesis, remain unknown. In the immune system, the highly diverse array of antigen receptors can be - tributed to the stochastic nature of the recombination process in somatic precursor cells, causing permanent changes in DNA and gene expression. This diverse population is then the target of selective processes that favor the correct antigen-receptor match and eliminate those with inadequate speci?cities, accounting for the rapid kinetics and immense diversity observed in vivo. Evidence for a possible similarity between the nervous and immune systems came from studies with mice de?cient in DNA double strand break (DSB) repair. Lessons learned from the discovery of the mechanism for diversityinthe immune system maybe usefultothe investigation ofthe mechanism of diversity in neurons.
