Handbook of Experimental Pharmacology

Pharmacology of Neurotransmitter Release

Editors: Südhof, Thomas C., Starke, Klaus (Eds.)

  • Analyses the molecular events of exocytosis

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eBook $289.00
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  • ISBN 978-3-540-74804-5
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About this book

It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book’s second part, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process. These include ligand-gated ion channels and presynaptic G-protein-coupled receptors. The targets of presynaptic receptors within the exocytosis cascade, and their therapeutic potential, are subjects addressed in the majority of chapters.

Table of contents (17 chapters)

  • Neurotransmitter Release

    Süudhof, Thomas C.

    Pages 1-21

  • Pharmacology of Neurotransmitter Release: Measuring Exocytosis

    Khvotchev, Mikhail (et al.)

    Pages 23-43

  • Presynaptic Calcium Channels: Structure, Regulators, and Blockers

    Kisilevsky, Alexandra E. (et al.)

    Pages 45-75

  • Pharmacology of Neurotransmitter Transport into Secretory Vesicles

    Chaudhry, Farrukh A. (et al.)

    Pages 77-106

  • Core Proteins of the Secretory Machinery

    Lang, Thorsten (et al.)

    Pages 107-127

Buy this book

eBook $289.00
price for USA (gross)
  • ISBN 978-3-540-74805-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $369.00
price for USA
  • ISBN 978-3-540-74804-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $369.00
price for USA
  • ISBN 978-3-642-09424-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmacology of Neurotransmitter Release
Editors
  • Thomas C. Südhof
  • Klaus Starke
Series Title
Handbook of Experimental Pharmacology
Series Volume
184
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-74805-2
DOI
10.1007/978-3-540-74805-2
Hardcover ISBN
978-3-540-74804-5
Softcover ISBN
978-3-642-09424-8
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XIV, 582
Topics