Progress in Molecular and Subcellular Biology

Viruses and Apoptosis

Editors: Alonso, Covadonga (Ed.)

  • Describes molecular pathways controlled by viral genes and how research in this area opens opportunities in cancer therapy
  • Uses different viral models to analyze molecular pathways regulated by viral genes and their role in the pathogenesis of infection
  • Explores particular cell types in apoptosis, such as neuronal cells and lymphoid cells
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About this book

The pathogenesis of viral infections involves dynamic interactions between viruses and hosts,which can result in different outcomes including cell death, elimination of the virus or latent infection.Viruses deliver genomes and p- teins with signaling potential into target cells, resulting in growth, prolife- tion and apoptosis.Viral infection modi?es key cell regulatory elements involved in apoptotic pathways to successfully accomplish viral replication despite the toxicity of viral products and the immune response elicited against the virus.Also,the interplay between virus-induced apoptosis and cell survival is mediated by an accurate balance between pro-death and anti-apoptotic signals triggered by cellular and viral proteins.Hence,viral survival products causing a delay in the completion of apoptotic process can be critical in the replication and propagation of viruses. Viral control of apoptosis can be a double-edged sword.In some viral inf- tions, immune cell apoptosis will contribute to pathogenesis and determine disease evolution either by direct infection of immune cells or as a result of bystander cell apoptosis caused by viral proteins or mediators secreted from infected cells. The apoptotic mechanisms contributing to HIV pathogenesis, the functional consequences on the immune system and the effect of antiviral therapies on this process will be reviewed in depth in this Volume.

Table of contents (15 chapters)

  • Cell Death Suppressors Encoded by Cytomegalovirus

    Goldmacher, V. S.

    Pages 1-18

  • Apoptosis Regulator Genes Encoded by Poxviruses

    Barry, M. (et al.)

    Pages 19-37

  • T-Cell-Mediated Control of Poxvirus Infection in Mice

    Müllbacher, A. (et al.)

    Pages 39-55

  • Switching on and Off the Cell Death Cascade: African Swine Fever Virus Apoptosis Regulation

    Hernáez, B. (et al.)

    Pages 57-69

  • Neuronal Apoptosis Pathways in Sindbis Virus Encephalitis

    Irusta, Pablo M. (et al.)

    Pages 71-93

Buy this book

eBook $84.99
price for USA (gross)
  • ISBN 978-3-540-74264-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA
  • ISBN 978-3-540-74263-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Viruses and Apoptosis
Editors
  • Covadonga Alonso
Series Title
Progress in Molecular and Subcellular Biology
Series Volume
36
Copyright
2004
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-74264-7
DOI
10.1007/978-3-540-74264-7
Softcover ISBN
978-3-540-74263-0
Series ISSN
0079-6484
Edition Number
1
Number of Pages
XVI, 342
Number of Illustrations and Tables
16 b/w illustrations
Topics