Topics in Medicinal Chemistry

Alzheimer's Disease

Editors: Bradbury, Rob, Brodney, Michael A. (Eds.)

  • An overview chapter introduces the newcomer to the topic covered
  • Part of a series that covers hot topics of frontier research summarized by reputed scientists in the field
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About this book

Alzheimer’s disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. The aging population in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which comes many ideas for intervening with its progression. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases (e.g. atorvastatin, simvastatin, rosiglitazone and clioquinol) while others represent novel chemical entities (e.g. glycogen synthase kinase-3 inhibitors).

This volume will first review existing cholinesterase inhibitors prescribed for AD patients followed by some target mechanisms with ongoing clinical trials. It offers a glimpse of what our future medicine cabinets may look like for AD patients. It also provides an interesting read on why and how current medicines for other indications could potentially be used to treat AD.

Table of contents (6 chapters)

  • Therapeutic Approaches for the Treatment of Alzheimer's Disease: An Overview

    Lau, Lit-Fui (et al.)

    Pages 1-24

  • Cholinesterase Inhibitors

    Kao, Jeffrey (et al.)

    Pages 25-51

  • Beyond Cholesterol: Statin Benefits in Alzheimer's Disease

    Soares, Holly D. (et al.)

    Pages 53-80

  • PPARγ Agonists for the Treatment of Alzheimer's Disease

    Jiang, Qingguang (et al.)

    Pages 81-106

  • Metal Complexing Agents for the Treatment of Alzheimer's Disease

    White, Anthony R. (et al.)

    Pages 107-136

Buy this book

eBook $259.00
price for USA (gross)
  • ISBN 978-3-540-74229-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $329.00
price for USA
  • ISBN 978-3-540-74228-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $329.00
price for USA
  • ISBN 978-3-642-09354-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Alzheimer's Disease
Editors
  • Rob Bradbury
  • Michael A. Brodney
Series Title
Topics in Medicinal Chemistry
Series Volume
2
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-74229-6
DOI
10.1007/978-3-540-74229-6
Hardcover ISBN
978-3-540-74228-9
Softcover ISBN
978-3-642-09354-8
Series ISSN
1862-2461
Edition Number
1
Number of Pages
XIII, 179
Topics