Telomeres and Telomerase in Aging, Disease, and Cancer

Molecular Mechanisms of Adult Stem Cell Ageing

Editors: Rudolph, K. Lenhard (Ed.)

  • Provides an in depth review of our current knowledge on the role of telomeres and telomerase in ageing, disease and cancer
  • Places special focus on adult stem cells
  • Describes future directions in research on adult stem cell ageing, telomeres, and cancer
  • Serves as an excellent basis for academic teachers, scientists, and students interested in the areas of stem cell ageing, telomeres and telomerase, regeneration, and cancer
  • Will be of interest to physicians since the development of molecular therapies targeting ageing stem cells represents a promising approach to improve regenerative reserve and organ function during ageing and could also serve to target cancer stem cells
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eBook $229.00
price for USA (gross)
  • ISBN 978-3-540-73709-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-540-73708-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-3-642-09288-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly.

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction.

A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.

All of these subjects are of great interest for ageing researchers, physicians and students and should provide a rational basis for beginning to identify molecular targets for novel therapies that aim to improve quality of life during ageing.

Table of contents (2 chapters)

  • Telomeres, Senescence, Oxidative Stress, and Heterogeneity

    João F. Passos, Glyn Nelson, Thomas von Zglinicki

    Pages 43-56

  • Senescence Signatures of Human Hematopoietic Stem Cells

    Stefan Zimmermann, Uwe M. Martens

    Pages 141-159

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-540-73709-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-540-73708-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-3-642-09288-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Telomeres and Telomerase in Aging, Disease, and Cancer
Book Subtitle
Molecular Mechanisms of Adult Stem Cell Ageing
Editors
  • K. Lenhard Rudolph
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-73709-4
DOI
10.1007/978-3-540-73709-4
Hardcover ISBN
978-3-540-73708-7
Softcover ISBN
978-3-642-09288-6
Edition Number
1
Number of Pages
XIV, 330
Number of Illustrations and Tables
39 b/w illustrations, 25 illustrations in colour
Topics