Ernst Schering Foundation Symposium Proceedings

Sparking Signals

Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation

Editors: Baier, G., Schraven, B., Zügel, U., von Bonin, A. (Eds.)

  • Internationally well known experts presented their most recent findings on the fast developing kinase field
  • Outstanding interest for basic researchers and the pharmaceutical industry
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eBook $99.00
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  • ISBN 978-3-540-73501-4
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  • ISBN 978-3-540-73500-7
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Softcover $129.00
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  • ISBN 978-3-642-09262-6
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About this book

Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.

Table of contents (9 chapters)

  • Proteomics-Based Strategies in Kinase Drug Discovery

    Bantscheff, M. (et al.)

    Pages 1-28

  • PKC Isotype Functions in T Lymphocytes

    Baier, G.

    Pages 29-41

  • Migration, Cell–Cell Interaction and Adhesion in the Immune System

    Gunzer, M.

    Pages 97-137

  • Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts

    Vestweber, D.

    Pages 151-167

  • Fragment-Based Drug Discovery Using Rational Design

    Jhoti, H.

    Pages 169-185

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-540-73501-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-540-73500-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA
  • ISBN 978-3-642-09262-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sparking Signals
Book Subtitle
Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation
Editors
  • Gottfried Baier
  • Burkhart Schraven
  • Ulrich Zügel
  • Arne von Bonin
Series Title
Ernst Schering Foundation Symposium Proceedings
Series Volume
2007/3
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-73501-4
DOI
10.1007/978-3-540-73501-4
Hardcover ISBN
978-3-540-73500-7
Softcover ISBN
978-3-642-09262-6
Series ISSN
0947-6075
Edition Number
1
Number of Pages
XIV, 187
Topics