Overview
- Recent developments in the emerging field of cancer stem cells
- Possible impact for the identification of novel treatment paradigms for cancer
Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 2006/5)
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Table of contents (14 papers)
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Front Matter
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Back Matter
Keywords
About this book
Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end points.
Bibliographic Information
Book Title: Cancer Stem Cells
Book Subtitle: Novel Concepts and Prospects for Tumor Therapy
Editors: O.D. Wiestler, B. Haendler, D. Mumberg
Series Title: Ernst Schering Foundation Symposium Proceedings
DOI: https://doi.org/10.1007/978-3-540-70853-7
Publisher: Springer Berlin, Heidelberg
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2007
Hardcover ISBN: 978-3-540-70852-0Published: 04 September 2007
Softcover ISBN: 978-3-642-42086-3Published: 28 November 2014
eBook ISBN: 978-3-540-70853-7Published: 03 August 2007
Series ISSN: 0947-6075
Edition Number: 1
Number of Pages: XVI, 263
Topics: Cancer Research, Oncology, Human Genetics