Springer Series in Biophysics

Non-Protein Coding RNAs

Editors: Walter, Nils, Woodson, Sarah A., Batey, Robert T. (Eds.)

  • Biophysical perspective on a rapidly expanding number of non-protein coding RNAs
  • Overview on how non-protein coding RNAs work and how biophysical techniques and other probing techniques help delineate the molecular underpinnings of RNA function
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eBook $229.00
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  • ISBN 978-3-540-70840-7
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Hardcover $289.00
price for USA
  • ISBN 978-3-540-70833-9
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  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
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  • ISBN 978-3-642-08980-0
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About this book

This book assembles chapters from experts in the Biophysics of RNA to provide a broadly accessible snapshot of the current status of this rapidly expanding field. The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, highlighting just one example of a large number of non-protein coding RNAs. Because non-protein coding RNAs outnumber protein coding genes in mammals and other higher eukaryotes, it is now thought that the complexity of organisms is correlated with the fraction of their genome that encodes non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic transposons, higher-level organization of eukaryotic chromosomes, and gene expression itself are found to largely be directed by non-protein coding RNAs. The biophysical study of these RNAs employs X-ray crystallography, NMR, ensemble and single molecule fluorescence spectroscopy, optical tweezers, cryo-electron microscopy, and other quantitative tools. This emerging field has begun to unravel the molecular underpinnings of how RNAs fulfill their multitude of roles in sustaining cellular life. The physical and chemical understanding of RNA biology that results from biophysical studies is critical to our ability to harness RNAs for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry.

Table of contents (17 chapters)

  • RNA 3D Structural Motifs: Definition, Identification, Annotation, and Database Searching

    Nasalean, Lorena (et al.)

    Pages 1-26

  • Theory of RNA Folding: From Hairpins to Ribozymes

    Thirumalai, D. (et al.)

    Pages 27-47

  • Thermodynamics and Kinetics of RNA Unfolding and Refolding

    Li, Pan T. X. (et al.)

    Pages 49-72

  • Ribozyme Catalysis of Phosphodiester Bond Isomerization: The Hammerhead RNA and Its Relatives

    Scott, William G.

    Pages 73-102

  • The Small Ribozymes: Common and Diverse Features Observed Through the FRET Lens

    Walter, Nils G. (et al.)

    Pages 103-127

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-3-540-70840-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-540-70833-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-3-642-08980-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Non-Protein Coding RNAs
Editors
  • Nils Walter
  • Sarah A. Woodson
  • Robert T. Batey
Series Title
Springer Series in Biophysics
Series Volume
13
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-70840-7
DOI
10.1007/978-3-540-70840-7
Hardcover ISBN
978-3-540-70833-9
Softcover ISBN
978-3-642-08980-0
Series ISSN
0932-2353
Edition Number
1
Number of Pages
XI, 398
Topics