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Proteome Research: Mass Spectrometry

  • Book
  • © 2001

Overview

Authors:
  1. Peter James

    1. Protein Chemistry Laboratory, ETH-Zentrum, Zürich, Switzerland

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  • The first book to extensively cover the applications of mass spectrometry to proteome research

Part of the book series: Principles and Practice (PRINCIPLES)

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-XXI
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  2. Mass Spectrometry and the Proteome

    • Peter James
    Pages 1-9

  3. Basics of Triple-Stage Quadrupole/Ion-Trap Mass Spectrometry: Precursor, Product and Neutral-Loss Scanning. Electrospray Ionisation and Nanospray Ionisation

    • David Arnott
    Pages 11-31

  4. The Basics of Matrix-Assisted Laser Desorption, Ionisation Time-of-Flight Mass Spectrometry and Post-Source Decay Analysis

    • Bernhard Spengler
    Pages 33-53

  5. Data-Controlled Micro-Scale Liquid Chromatography — Tandem Mass Spectrometry of Peptides and Proteins: Strategies for Improved Sensitivity, Efficiency and Effectiveness

    • Douglas C. Stahl, Terry D. Lee
    Pages 55-74

  6. Solid-Phase Extraction-Capillary Zone Electrophoresis-Mass Spectrometry Analysis of Low-Abundance Proteins

    • Daniel Figeys, Ruedi Aebersold
    Pages 75-101

  7. Protein Identification by Peptide-Mass Fingerprinting

    • Paola Dainese, Peter James
    Pages 103-123

  8. Protein Identification by SEQUEST

    • David L. Tabb, Jimmy K. Eng, John R. Yates III
    Pages 125-142

  9. Interpreting Peptide Tandem Mass-Spectrometry Fragmentation Spectra

    • Werner Staudenmann, Peter James
    Pages 143-166

  10. Automated Interpretation of Peptide Tandem Mass Spectra and Homology Searching

    • Richard S. Johnson
    Pages 167-185

  11. Specific Detection and Analysis of Phosphorylated Peptides by Mass Spectrometry

    • Manfredo Quadroni
    Pages 187-206

  12. Glycoproteomics: High-Throughput Sequencing of Oligosaccharide Modifications to Proteins

    • Pauline M. Rudd, Cristina Colominas, Louise Royle, Neil Murphy, Edmund Hart, Anthony H. Merry et al.
    Pages 207-228

  13. Proteomics Databases

    • Hanno Langen, Peter Berndt
    Pages 229-257

  14. Quo Vadis

    • Peter James
    Pages 259-270

  15. Back Matter

    Pages 271-274
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Keywords

About this book

Recent advances in large-scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Two-dimensional gel electrophoresis can be used to create cellular protein maps which give a quantitative and qualitative picture of the proteome. Mass spectrometry is the method of choice for the rapid large-scale idenfification of these proteomes and their modifications. An understanding of these methods is critical for scientists in the "Post-Genome" era.

Authors and Affiliations

  • Protein Chemistry Laboratory, ETH-Zentrum, Zürich, Switzerland

    Peter James

Bibliographic Information

  • Book Title: Proteome Research: Mass Spectrometry

  • Authors: Peter James

  • Series Title: Principles and Practice

  • DOI: https://doi.org/10.1007/978-3-642-56895-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2001

  • Hardcover ISBN: 978-3-540-67255-5Published: 26 October 2000

  • Softcover ISBN: 978-3-540-67256-2Published: 26 October 2000

  • eBook ISBN: 978-3-642-56895-4Published: 01 December 2013

  • Series ISSN: 1866-914X

  • Series E-ISSN: 1866-9158

  • Edition Number: 1

  • Number of Pages: XXI, 274

  • Topics: Proteomics, Cell Biology, Human Genetics, Biotechnology, Molecular Medicine, Cancer Research

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