Current Topics in Microbiology and Immunology

Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Transduction of BCR Signals from the Cell Membrane to the Nucleus

Editors: Justement, Louis B., Siminovitch, Katherine A. (Eds.)

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About this book

Proper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au­ toreactive B cells to exist in the periphery where they may com­ plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re­ straints that effectively attenuate their ability to respond to self­ antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

Table of contents (7 chapters)

  • Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases

    Justement, Louis B.

    Pages 1-51

  • The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins

    Wienands, J.

    Pages 53-76

  • Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus

    Gold, M. R.

    Pages 77-134

  • Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signaling

    Cruz, L. A. G. (et al.)

    Pages 135-167

  • Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes

    Hagman, J. (et al.)

    Pages 169-194

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-642-57066-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-3-540-66002-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-3-642-63017-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Signal Transduction and the Coordination of B Lymphocyte Development and Function I
Book Subtitle
Transduction of BCR Signals from the Cell Membrane to the Nucleus
Editors
  • Louis B. Justement
  • Katherine A. Siminovitch
Series Title
Current Topics in Microbiology and Immunology
Series Volume
245/1
Copyright
2000
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-57066-7
DOI
10.1007/978-3-642-57066-7
Hardcover ISBN
978-3-540-66002-6
Softcover ISBN
978-3-642-63017-0
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XV, 267
Topics