Advances in Biochemical Engineering/Biotechnology

Biotransformations

Editors: Faber, K. (Ed.)

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About this book

The use of enzymes – employed either as isolated enzymes, crude protein extracts or whole cells – for the transformation of non-natural organic c- pounds is not an invention of the twentieth century: they have been used for more than one hundred years. However,the object of most of the early research was totally different from that of the present day. Whereas the elucidation of biochemical pathways and enzyme mechanisms was the main driving force for the early studies,in contrast it was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic c- pounds was recognized. This trend was particularly well enhanced by the recommendation of the FDA-guidelines (1992) with respect to the use of chiral bioactive agents in enantiopure form. During the last two decades, it has been shown that the substrate tolerance of numerous biocatalysts is often much wider than previously believed. Of course,there are many enzymes which are very strictly bound to their natural substrate(s). They play an important role in metabolism and they are gener- ly not applicable for biotransformations. On the other hand, an impressive number of biocatalysts have been shown to possess a wide substrate tolerance by keeping their exquisite catalytic properties with respect to chemo-, reg- and, most important, enantio-selectivity. This made them into the key tools for biotransformations.

Table of contents (8 chapters)

  • Biocatalytic Asymmetric Decarboxylation

    Ohta, Hiromichi

    Pages 1-30

  • Biocatalytic Applications of Hydroxynitrile Lyases

    Johnson, Dean V. (et al.)

    Pages 31-55

  • Stereoinversions Using Microbial Redox-Reactions

    Carnell, Andrew J.

    Pages 57-72

  • Biotransformations with Peroxidases

    Adam, Waldemar (et al.)

    Pages 73-108

  • Production of Chiral C3- and C4-Units by Microbial Enzymes

    Shimizu, Sakayu (et al.)

    Pages 109-123

Buy this book

eBook $84.99
price for USA (gross)
  • ISBN 978-3-540-69791-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA
  • ISBN 978-3-540-64496-5
  • Free shipping for individuals worldwide
  • Out of print
Softcover $109.99
price for USA
  • ISBN 978-3-540-66949-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biotransformations
Editors
  • K. Faber
Series Title
Advances in Biochemical Engineering/Biotechnology
Series Volume
63
Copyright
1999
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-69791-6
DOI
10.1007/3-540-69791-8
Hardcover ISBN
978-3-540-64496-5
Softcover ISBN
978-3-540-66949-4
Series ISSN
0724-6145
Edition Number
1
Number of Pages
VIII, 224
Number of Illustrations and Tables
33 b/w illustrations
Additional Information
Originally published as volume 63 in the series: Advances in Biochemical Engineering / Biotechnology
Topics