Metastatic Bone Disease

1. Front Matter

   Pages I-X

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2. Historical Remarks on Metastasis and Metastatic Bone Disease

   • I. J. Diel

   Pages 1-11

3. Nature of Metastatic Bone Disease

   • R. D. Rubens

   Pages 12-19

4. Incidence and Distribution of Bone Metastases

   • R. Coleman

   Pages 20-30

5. Detection and Characterization of Tumor Cells in Bone Marrow of Patients with Primary Breast Cancer

   • I. J. Diel, S. D. Costa, M. Kaufmann, G. Bastert

   Pages 31-45

6. Normal Bone Remodeling and Metastatic Bone Disease

   • B. F. Boyce, H. Chen

   Pages 46-58

7. Morphological Findings in Bone Metastasis, Tumorosteopathy and Antiosteolytic Therapy

   • B. Krempien

   Pages 59-85

8. Mechanisms of Osteolytic Bone Destruction

   • G. R. Mundy, B. F. Boyce, T. Yoneda

   Pages 86-92

9. Diagnosis of Skeletal Metastases and Assessment of Response to Treatment

   • C. S. B. Galasko

   Pages 93-108

10. Biochemical Markers of Bone Metabolism in Metastatic Bone Disease

    • M. J. Seibel, I. Lambrinoudaki, A. Zipf

    Pages 109-126

11. Palliative Radiotherapy of Bone Metastases

    • U. M. Lütolf, P. Huguenin, C. Glanzmann

    Pages 127-132

12. Systemic Treatment of Bone Metastases: Review of Literature and Retrospective Analysis of 718 Breast Cancer Patients

    • S. D. Costa, I. J. Diel, E. Solomayer, G. von Minckwitz, G. Bastert

    Pages 133-143

13. Bisphosphonates: Mechanisms of Action and Clinical Use in Hypercalcemia of Malignancy and Tumor-Induced Bone Destruction

    • H. Fleisch

    Pages 144-176

14. Clodronate Decreases Skeletal Morbidity in Patients with Bone Metastases from Breast Cancer: A Double-Blind Randomised Controlled Trial

    • T. J. Powles, A. H. G. Paterson, J. A. Kanis

    Pages 177-179

15. Back Matter

    Pages 180-186

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"Metastatic Bone Disease: Fundamental and Clinical Aspects" is an expanded version of a workshop on bone metastases which was held in Heidelberg, Germany, in April 1993. Bone metastases very often develop from malignant tumors and lead to complications which considerably diminish the quality of life of the patient. Bone pain, pathological fractures, and hypercalcemic syndrome should be recognized and treated ear- ly, so as to prevent any further morbidity and immobilizati- on. Antiosteolytic substances such as biophosphonate can supplement the established palliative and supportive thera- pies. Highly qualified basic researchers and clinicians in pathophysiology, diagnosis, and treatment of metastatic bone disease have contributed to this book, providing a good overview ofpresent knowledge and research. The book will be of interest not only to specialists, but also to any physi- cian interested in oncology.

• Bone Metastases
• Diagnose und Behandlung
• Diagnosis and Treatment
• Knochemetastasen
• Oncology
• Onkologie
• Pathophysiologie
• Pathophysiology
• Skeleton Disease
• morbidity
• skeleterale Erkrankungen

• Universitäts-Frauenklinik, Heidelberg, Germany

  Ingo J. Diel, M. Kaufmann, G. Bastert

Policies and ethics