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Tissue Oxygen Utilization

  • Book
  • © 1991

Overview

Editors:
  1. Guillermo Gutierrez

    1. Pulmonary Medicine, Health Science Center, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Jean Louis Vincent

    1. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Update in Intensive Care and Emergency Medicine (UICM, volume 12)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-ix
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  2. Intracellular Oxygen Supply: Implications for Intensive Care

    • D. P. Jones, T. Y. Aw, D. P. Kowalski
    Pages 1-15

  3. NMR Investigations of Cardiac Metabolism

    • A.-M. Seymour
    Pages 16-32

  4. Evaluation of Tissue Hypoxia by Optical Methods

    • B. Chance
    Pages 33-40

  5. Application of NIR Spectroscopy to Problems of Tissue Oxygenation

    • C. A. Piantadosi, W. J. Parsons, J. A. Griebel
    Pages 41-55

  6. Principal Determinants of Tissue PO2: Clinical Considerations

    • T. E. Gayeski
    Pages 56-70

  7. Cellular Metabolic Consequences of Altered Perfusion

    • H. Haljamäe
    Pages 71-86

  8. Vascular Response to Hypoxia

    • J. Almirall, G. Hedenstierna
    Pages 87-102

  9. Blood Rheology Factors and Capillary Blood Flow

    • K. Messmer
    Pages 103-113

  10. Physiological and Pathological Oxygen Supply Dependency

    • S. M. Cain
    Pages 114-123

  11. Oxygen Delivery and Utilization in Acute and Chronic Disease

    • D. R. Dantzker
    Pages 124-131

  12. Oxygen Transport and Uptake in Health and Disease

    • P. T. Schumacker, R. W. Samsel
    Pages 132-142

  13. Multiple Organ Oxygen Supply-Demand Relationships and Redistribution of Flow

    • R. Schlichtig, J. V. Snyder, M. R. Pinsky
    Pages 143-159

  14. The Determinants of Maximum Oxygen Utilization: The Role of Hemoglobin Concentration

    • P. D. Wagner
    Pages 160-170

  15. Oxygen Cost of Breathing

    • S. Zakynthinos, C. Roussos
    Pages 171-184

  16. Myocardial Oxygen Metabolism in the Sepsis Syndrome

    • W. J. Sibbald
    Pages 185-199

  17. Tissue Oxygen Utilization in Septic Shock

    • L. G. Thijs, A. B. J. Groeneveld
    Pages 200-216

  18. Oxygen Supply Dependency in Septic Shock

    • J.-F. Dhainaut, G. Annat, A. Armaganidis
    Pages 217-226

  19. Cellular Metabolism in Sepsis

    • G. Gutierrez, A. Dubin
    Pages 227-241

  20. Multiple Organ Failure: Is It Only Hypoxia?

    • F. B. Cerra
    Pages 242-251
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Keywords

About this book

Disturbances in peripheral O extraction can be produced in dogs treated with 2 endotoxin and thereby provide an opportunity to test theories for the origin of pathological O supply dependency or to try different treatment modalities. The 2 most serious deficiency in the current animal models is the inability to mimic the increased O demand that is observed in patients at 02 delivery rates in excess of 2 normal. A particular feature of this increased O demand is that it apparently does 2 not stimulate increased 02 extraction, although the limitation in O extraction has 2 not been explored in patients by lowering 02 supply, for obvious reasons. At least two possibilities to account for increased 02 demand could be investigated in animal models, however. The amount of 02 that is utilized in extramitochondrial pathways, which is normally on the order of 10%, may be greatly increased in ARDS and sepsis by O radical formation. There is presently no information 2 concerning how much 02 might be used in this way. Another strong possibility is that mitochondrial injury, perhaps as a result of 02 radical formation, uncouples oxidative phosphorylation. Some evidence presently in the literature supports this idea [19]. Indeed, the association of increased blood lactate levels with higher than expected 02 demands makes uncoupling a very attractive hypothesis that warrants further investigation in animal models using such agents as 2,4-dinitrophenol. References 1.

Editors and Affiliations

  • Pulmonary Medicine, Health Science Center, Houston, USA

    Guillermo Gutierrez

  • Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium

    Jean Louis Vincent

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