Ernst Schering Foundation Symposium Proceedings

Tissue-Specific Estrogen Action

Novel Mechanisms, Novel Ligands, Novel Therapies

Editors: Korach, Kenneth S., Wintermantel, Tim (Eds.)

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Hardcover $149.00
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  • ISBN 978-3-540-49547-5
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Softcover $149.00
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  • ISBN 978-3-642-42103-7
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About this book

Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s—and therefore several decades longer than nuclear receptor - searchitself—estrogenreceptorshavebeentargetsofwidelyused,orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.

Reviews

From the reviews:

"This summation of a symposium discusses some of the new research developments and estrogen-receptor based therapies that are being tested in the laboratory and in current use. … It is written for researchers, physician scientists, and those interested in estrogen receptor interactions at a molecular level. Hopefully, it can also stimulate interest in and future research by graduate students or clinical/basic researchers." (Amber R. Cooper, Doody’s Review Service, January 2008)


Table of contents (10 chapters)

  • Interfering with the Dynamics of Estrogen Receptor-Regulated Transcription

    Johnsen, S. A. (et al.)

    Pages 1-12

  • Actions of Estrogen and Estrogen Receptors in Nonclassical Target Tissues

    Murphy, E. (et al.)

    Pages 13-24

  • Genetic Dissection of Estrogen Receptor Signaling In Vivo

    Wintermantel, T. M. (et al.)

    Pages 25-44

  • Of Mice and Men: The Many Guises of Estrogens

    Simpson, E. R. (et al.)

    Pages 45-68

  • Estradiol Action in Atherosclerosis and Reendothelialization

    Arnal, J.- F. (et al.)

    Pages 69-86

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-540-49548-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.00
price for USA
  • ISBN 978-3-540-49547-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.00
price for USA
  • ISBN 978-3-642-42103-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tissue-Specific Estrogen Action
Book Subtitle
Novel Mechanisms, Novel Ligands, Novel Therapies
Editors
  • Kenneth S. Korach
  • Tim Wintermantel
Series Title
Ernst Schering Foundation Symposium Proceedings
Series Volume
2006/1
Copyright
2007
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-49548-2
DOI
10.1007/978-3-540-49548-2
Hardcover ISBN
978-3-540-49547-5
Softcover ISBN
978-3-642-42103-7
Series ISSN
0947-6075
Edition Number
1
Number of Pages
XV, 181
Topics