Recent Results in Cancer Research

Chemosensitivity Testing in Oncology

Editors: Reinhold, Uwe, Tilgen, Wolfgang (Eds.)

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About this book

Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

Table of contents (18 chapters)

  • Luminescence Applications for Chemotherapeutic Drug Development

    Andreotti, Peter E. (et al.)

    Pages 3-12

  • The Use of the MTT Assay to Study Drug Resistance in Fresh Tumour Samples

    Sargent, Jean M.

    Pages 13-25

  • Chemosensitivity Testing of Human Tumors Using Si-sensor Chips

    Mestres-Ventura, Pedro

    Pages 26-38

  • Multiparametric Sensor Chips for Chemosensitivity Testing of Sensitive and Resistant Tumor Cells

    Otto, Angela M. (et al.)

    Pages 39-47

  • Development of a New In Vitro Chemosensitivity Test Using Collagen Gel Droplet Embedded Culture and Image Analysis for Clinical Usefulness

    Kobayashi, Hisayuki

    Pages 48-61

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-642-19022-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-540-43468-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-62412-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chemosensitivity Testing in Oncology
Editors
  • Uwe Reinhold
  • Wolfgang Tilgen
Series Title
Recent Results in Cancer Research
Series Volume
161
Copyright
2003
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-19022-3
DOI
10.1007/978-3-642-19022-3
Hardcover ISBN
978-3-540-43468-9
Softcover ISBN
978-3-642-62412-4
Series ISSN
0080-0015
Edition Number
1
Number of Pages
X, 245
Topics