Research and Perspectives in Alzheimer's Disease

Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate

Editors: Israel, A., Strooper, B. de, Checler, F., Christen, Y. (Eds.)

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About this book

Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.

Table of contents (12 chapters)

  • Regulated Intramembrane Proteolysis — New Lessons from Lipid Metabolism and the Unfolded Protein Response

    Rawson, R. B.

    Pages 1-17

  • Notch Signaling in the Brain: More than Just a Developmental Story

    Šestan, N. (et al.)

    Pages 19-40

  • Control of Notch Activity by the Ubiquitin-Proteasome Pathway

    Gupta-Rossi, N. (et al.)

    Pages 41-58

  • A Presenilin Dependent S3-Like γ-Secretase Cleavage of the β-Amyloid Precursor Protein

    Steiner, H. (et al.)

    Pages 59-61

  • New Non-Peptidic Inhibitors of γ-Secretase Abolish Aβ Production Without Modifying Notch Cleavage

    Petit, A. (et al.)

    Pages 63-70

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-3-642-55996-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-3-540-43073-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $99.00
price for USA
  • ISBN 978-3-642-62767-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate
Editors
  • Alain Israel
  • B. de Strooper
  • F. Checler
  • Y. Christen
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2002
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-55996-9
DOI
10.1007/978-3-642-55996-9
Hardcover ISBN
978-3-540-43073-5
Softcover ISBN
978-3-642-62767-5
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XVI, 158
Topics