Update in Intensive Care and Emergency Medicine

Mechanisms of Organ Dysfunction in Critical Illness

Editors: Evans, Timothy W., Fink, Mitchell P. (Eds.)

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About this book

The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

Table of contents (28 chapters)

  • Cellular Responses to Hypoxia: Role of Oxidant Signal Transduction

    Schumacker, P. T.

    Pages 3-16

  • The Mitochondrial Permeability Transition: A‘Pore’Way to Die

    Halestrap, A. P. (et al.)

    Pages 17-39

  • Cytopathic Hypoxia in Circulatory Shock: The Role of Poly (ADP-Ribose) Synthetase Activation

    Szabó, C.

    Pages 40-51

  • Derangements in Cellular Oxygen Metabolism

    Leverve, X. M.

    Pages 52-68

  • Pharmacologic and Metabolic Mitochondrial Rescue

    Weinberg, J. M. (et al.)

    Pages 69-91

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-3-642-56107-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-3-540-42193-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $175.00
price for USA
  • ISBN 978-3-540-42692-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Organ Dysfunction in Critical Illness
Editors
  • Timothy W. Evans
  • Mitchell P. Fink
Series Title
Update in Intensive Care and Emergency Medicine
Series Volume
38
Copyright
2002
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-56107-8
DOI
10.1007/978-3-642-56107-8
Hardcover ISBN
978-3-540-42193-1
Softcover ISBN
978-3-540-42692-9
Series ISSN
0933-6788
Edition Number
1
Number of Pages
XVI, 410
Topics