Ernst Schering Foundation Symposium Proceedings

New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

Editors: Korach, Kenneth S., Hillisch, Alexander, Fritzemeier, Karl Heinrich (Eds.)

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About this book

From our current knowledge, it is obvious that estrogen action in­ volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes­ tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non­ genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted.

Table of contents (13 chapters)

  • Estrogens: From Classical Endocrine Action to Tissue Selective Action

    Lyttle, C. R. (et al.)

    Pages 1-21

  • Identification of RIP140 as a Nuclear Receptor Cofactor with a Role in Female Reproduction

    Parker, M. (et al.)

    Pages 23-31

  • A Structural Explanation for ERα/ERβ SERM Discrimination

    Greene, G. L. (et al.)

    Pages 33-45

  • Protein Structure-Based Design, Synthesis Strategy and In Vitro Pharmacological Characterization of Estrogen Receptor α and β Selective Compounds

    Hillisch, A. (et al.)

    Pages 47-62

  • How to Understand Estrogen Signaling from the Phenotypes of ERα and ERβ Knockout Mice

    Warner, M. (et al.)

    Pages 63-77

Buy this book

eBook $89.00
price for USA (gross)
  • ISBN 978-3-662-05386-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-3-540-40250-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $119.00
price for USA
  • ISBN 978-3-662-05388-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy
Editors
  • Kenneth S. Korach
  • Alexander Hillisch
  • Karl Heinrich Fritzemeier
Series Title
Ernst Schering Foundation Symposium Proceedings
Series Volume
46
Copyright
2004
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-662-05386-7
DOI
10.1007/978-3-662-05386-7
Hardcover ISBN
978-3-540-40250-3
Softcover ISBN
978-3-662-05388-1
Series ISSN
0947-6075
Edition Number
1
Number of Pages
XVI, 214
Number of Illustrations and Tables
82 b/w illustrations, 12 illustrations in colour
Topics