Ernst Schering Foundation Symposium Proceedings

Leucocyte Trafficking

The Role of Fucosyltransferases and Selectins

Editors: Hamann, A., Asadullah, Khusru, Schottelius, A. (Eds.)

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  • ISBN 978-3-662-05397-3
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  • ISBN 978-3-540-40112-4
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About this book

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

Table of contents (11 chapters)

  • Selectin Ligands on T Cells

    Hamann, A. (et al.)

    Pages 1-14

  • Skin Homing T Cells

    Akdis, M. (et al.)

    Pages 15-26

  • Cutaneous Lymphocyte Localization in the Pathogenesis of Psoriasis

    Schön, M. P.

    Pages 27-51

  • The Role of Fucosylation in Leukocyte Adhesion Deficiency II

    Vestweber, D. (et al.)

    Pages 53-74

  • Substrate Specificity and Synthetic Use of Glycosyltransferases

    Thiem, J.

    Pages 75-94

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-3-662-05397-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-3-540-40112-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-3-662-05399-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Leucocyte Trafficking
Book Subtitle
The Role of Fucosyltransferases and Selectins
Editors
  • A. Hamann
  • Khusru Asadullah
  • A. Schottelius
Series Title
Ernst Schering Foundation Symposium Proceedings
Series Volume
44
Copyright
2004
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-662-05397-3
DOI
10.1007/978-3-662-05397-3
Hardcover ISBN
978-3-540-40112-4
Softcover ISBN
978-3-662-05399-7
Series ISSN
0947-6075
Edition Number
1
Number of Pages
XIV, 242
Topics