Research and Perspectives in Endocrine Interactions

Insights into Receptor Function and New Drug Development Targets

Editors: Conn, P.Michael, Kordon, Claude (Eds.)

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About this book

G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function.

The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.

The completion of the human genome has identified a new source of therapeutic targets: "orphan receptors" with unknown functions and yet-to-be discovered ligands. Some orphans have now been identified as ghrelin, nociceptin, apelin, and urocortin. This finding, along with important technologies to develop ligands with desirable characteristics, including peptidomimetics is likely to further accelerate interest in this area.

Table of contents (2 chapters)

  • Mutations in G proteins and G protein-coupled receptors in human endocrine diseases

    Allen Spiegel

    Pages

  • Receptor Tyrosine Kinases as Targets for Cancer Therapy Development

    Andreas Gschwind, Oliver M. Fischer, Axel Ullrich

    Pages

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-540-34447-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-540-34446-9
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $209.00
price for USA
  • ISBN 978-3-642-07080-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Insights into Receptor Function and New Drug Development Targets
Editors
  • P.Michael Conn
  • Claude Kordon
Series Title
Research and Perspectives in Endocrine Interactions
Copyright
2006
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-34447-6
DOI
10.1007/3-540-34447-0
Hardcover ISBN
978-3-540-34446-9
Softcover ISBN
978-3-642-07080-8
Series ISSN
1861-2253
Edition Number
1
Number of Pages
XV, 202
Topics