Advances in Biochemical Engineering/Biotechnology

Cell Culture Engineering

Editors: Hu, Wei-Shu (Ed.)

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About this book

Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.

Table of contents (5 chapters)

  • Established Bioprocesses for Producing Antibodies as a Basis for Future Planning

    Farid, Suzanne S.

    Pages 1-42

  • Fedbatch Culture and Dynamic Nutrient Feeding

    Wlaschin, Katie F. (et al.)

    Pages 43-74

  • The “Push-to-Low” Approach for Optimization of High-Density Perfusion Cultures of Animal Cells

    Konstantinov, Konstantin (et al.)

    Pages 75-98

  • Towards Industrial Application of Quasi Real-Time Metabolic Flux Analysis for Mammalian Cell Culture

    Goudar, Chetan (et al.)

    Pages 99-118

  • Engineering Cells for Cell Culture Bioprocessing – Physiological Fundamentals

    Seth, Gargi (et al.)

    Pages 119-164

Buy this book

eBook $289.00
price for USA (gross)
  • ISBN 978-3-540-34007-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $369.00
price for USA
  • ISBN 978-3-540-34006-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $369.00
price for USA
  • ISBN 978-3-642-07051-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cell Culture Engineering
Editors
  • Wei-Shu Hu
Series Title
Advances in Biochemical Engineering/Biotechnology
Series Volume
101
Copyright
2006
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-34007-2
DOI
10.1007/11751571
Hardcover ISBN
978-3-540-34006-5
Softcover ISBN
978-3-642-07051-8
Series ISSN
0724-6145
Edition Number
1
Number of Pages
XI, 168
Additional Information
With contributions by numerous experts
Topics