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  • Book
  • © 2005

Systems Biology

Definitions and Perspectives

  • Systems Biology is one of the new and fast developing fields in science.
  • This book is the first to give a comprehensive definition and overview, and to highlight the applications of systems biology
  • Includes supplementary material: sn.pub/extras

Part of the book series: Topics in Current Genetics (TCG, volume 13)

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Table of contents (19 chapters)

  1. Front Matter

  2. Systems Biology: Did we know it all along?

    • Hans V. Westerhoff, Lilia Alberghina
    Pages 3-9
  3. Kinetic modelling of the E. coli metabolism

    • Oleg V. Demin, Tatyana Y. Plyusnina, Galina V. Lebedeva, Ekaterina A. Zobova, Eugeniy A. Metelkin, Alex G. Kolupaev et al.
    Pages 31-67
  4. Metabolic Control Analysis

    • David A. Fell
    Pages 69-80
  5. Mesoscopic kinetics and its applications in protein synthesis

    • Johan Elf, Johan Paulsson, Otto Berg, MÃ¥ns Ehrenberg
    Pages 95-18
  6. What is systems biology? From genes to function and back

    • Hans V. Westerhoff, Jan-Hendrik S. Hofmeyr
    Pages 119-141
  7. Mechanistic and modular approaches to modeling and inference of cellular regulatory networks

    • Boris N. Kholodenko, Frank J. Bruggeman, Herbert M. Sauro
    Pages 143-159
  8. Modeling the E. coli cell: The need for computing, cooperation, and consortia

    • Barry L. Wanner, Andrew Finney, Michael Hucka
    Pages 163-189
  9. Metabolic networks: biology meets engineering sciences

    • A. Kremling, J. Stelling, K. Bettenbrock, S. Fischer, E.D. Gilles
    Pages 215-234
  10. Integration of metabolic and signaling networks

    • Dirk Müller, Luciano Aguilera-Vázquez, Matthias Reuss, Klaus Mauch
    Pages 235-256
  11. Mathematical modelling of the Wnt-pathway

    • Reinhart Heinrich
    Pages 259-275
  12. Modelling signalling pathways – a yeast approach

    • Bodil Nordlander, Edda Klipp, Bente Kofahl, Stefan Hohmann
    Pages 277-302
  13. Systems biology of the yeast cell cycle engine

    • Béla Novák, Katherine C. Chen, John J. Tyson
    Pages 305-324
  14. A modular systems biology analysis of cell cycle entrance into S-phase

    • Lilia Alberghina, Riccardo L. Rossi, Danilo Porro, Marco Vanoni
    Pages 325-347
  15. Systems biology of apoptosis

    • Martin Bentele, Roland Eils
    Pages 349-372
  16. Systems Biology: necessary developments and trends

    • Lilia Alberghina, Stefan Hohmann, Hans V. Westerhoff
    Pages 389-402

About this book

For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.

Bibliographic Information

Buy it now

Buying options

Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access