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Current Topics in Microbiology and Immunology

Signalling from Internalised Growth Factor Receptors

Editors: Madshus, Inger Helene (Ed.)

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  • ISBN 978-3-540-69494-6
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  • ISBN 978-3-540-21038-2
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About this book

This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.

Table of contents (6 chapters)

  • Receptor Tyrosine Kinase Signaling and Trafficking—Paradigms Revisited

    Barbieri, M. A. (et al.)

    Pages 1-20

  • Met Receptor Dynamics and Signalling

    Hammond, D. E. (et al.)

    Pages 21-44

  • Signaling, Internalization, and Intracellular Activity of Fibroblast Growth Factor

    Więdłocha, A. (et al.)

    Pages 45-79

  • Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction

    Strous, G. J. (et al.)

    Pages 81-118

  • Clathrin-Independent Endocytosis and Signalling of Interleukin 2 Receptors

    Gesbert, F. (et al.)

    Pages 119-148

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-3-540-69494-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-3-540-21038-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-3-642-05912-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Signalling from Internalised Growth Factor Receptors
Editors
  • Inger Helene Madshus
Series Title
Current Topics in Microbiology and Immunology
Series Volume
286
Copyright
2004
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-69494-6
DOI
10.1007/978-3-540-69494-6
Hardcover ISBN
978-3-540-21038-2
Softcover ISBN
978-3-642-05912-4
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 190
Number of Illustrations and Tables
27 b/w illustrations, 4 illustrations in colour
Topics