Lecture Notes in Biomathematics

Computer Simulation in Cell Radiobiology

Authors: Yakovlev, Andrej Yu., Zorin, Aleksandr V.

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About this book

The search for ways to overcome tumour radioresistance is a major problem of experimental and clinical radiation oncology. The diffi­ culties involved in the attempts to solve this problem are a matter of common knowledge. In many a laboratory extensive studies are un­ derway of factors determining tumour tissue response to irradiation and of methods for exerting directional effect upon those factors. Such studies have revealed that, at least at the cellular level, a considerable number of factors manifest themselves which are respon­ sible for radiation effect (1] • Among those are: spatial heteroge­ neity of tumour cell population producing radioresistant cell reser­ ves (hypoxic cells of solid tumours); differing radiosensitivities of cell life cycle phases; intrinsic dynamics of the processes of radi­ ation damage and postradiation cell recovery; induction of prolifera­ tive processes in response to the death of some cells within the po­ pulation; the stochastic nature of cell kinetics and complicated in­ teraction between individual cell subpopulations corresponding to di­ fferent tumour loci. Questions arise as to whether the researchers are now in possession of adequate means for interpreting experimental findings and clinical evidence and whether there are procedures for performing complex analysis and predicting specific tumour responses to various irradiation regimens and to combined antitumoral effects, taking into account the complexities of the phenomena under study.

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Buy this book

eBook $69.99 net
( price for USA )
  • ISBN 978-3-642-51716-7
  • digitally watermarked, no DRM
  • included format: PDF
  • eBooks can be used on all Reading Devices
Softcover $99.00 net
( price for USA )
  • ISBN 978-3-540-19457-6
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days

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Bibliographic Information

Bibliographic Information
Book Title
Computer Simulation in Cell Radiobiology
Series Title
Lecture Notes in Biomathematics
Series Volume
74
Copyright
1988
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-51716-7
DOI
10.1007/978-3-642-51716-7
Softcover ISBN
978-3-540-19457-6
Series ISSN
0341-633X
Edition Number
1
Topics