Advances in Anatomy, Embryology and Cell Biology

Glycogen and its Related Enzymes of Metabolism in the Central Nervous System

Authors: Ibrahim, M.Z.M.

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The glycogen content of normal mammalian CNS is small when compared with that of some other mammalian tissues such as liver and muscle. Nevertheless, this glycogen content normally comprises at least one quarter of its total reserve of energy, the rest being adenosine triphosphate (ATP), phosphocreatine and glucose. Since this glycogen undergoes a turnover 50-100 times that of brain lipids, and exceeds by several orders of magnitude that of liver glycogen, it most likely plays a dynamic role in the metabolism of brain, Gatfield et al. (1966), Prasannan and Subrahmanyam (1968b), Brunner et al. (1971), Edwards and Rogers (1972) and Watanabe and Passonneau (1973). Glycogen also has an unequal distribution in the normal mammalian brain and spinal cord (Shimizu and Kumamoto, 1952; Shimizu and Okada, 1957; Friede, 1966; Shanthaveerappa et al. , 1966; Ibrahim etal. , 1970a), and it is possible that areas showing more glycogen "are inherently vulnerable and that their extra glycogen is an added protective mechanism" (Ibrahim, 1972). However, this is probably not the only explanation for the unequal distribution of glycogen since it is suggested for instance that neuronal glycogen may be normally impliĀ­ cated in the process of synaptic transmission (Shanthaveerappa et al. , 1966; Drummond and Bellward, 1970) and that retinal glycogen plays a role in the normal dark-light adaptation sequence (Shimizu and Maeda, 1953). Also, a wide variety of physiological, pathological and experimental conditions leads to a common response in the CNS, namely, accumulation of glycogen.

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Buy this book

eBook $69.99 net
( price for USA )
  • ISBN 978-3-642-86875-7
  • digitally watermarked, no DRM
  • included format: PDF
  • eBooks can be used on all Reading Devices
Softcover $99.00 net
( price for USA )
  • ISBN 978-3-540-07454-0
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days

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Bibliographic Information

Bibliographic Information
Book Title
Glycogen and its Related Enzymes of Metabolism in the Central Nervous System
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
52/1
Copyright
1975
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-86875-7
DOI
10.1007/978-3-642-86875-7
Softcover ISBN
978-3-540-07454-0
Series ISSN
0301-5556
Edition Number
1
Topics