Current Topics in Microbiology and Immunology

Phosphoinositides in Subcellular Targeting and Enzyme Activation

Editors: Stenmark, Harald (Ed.)

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About this book

 

The reversible recruitment of intracellular protein complexes to membranes is essential for immune cell functions, including chemotaxis, phagocytosis and signalling. Such recruitment is often controlled by phosphorylated derivatives of phosphatidylinositol, known as phosphoinositides. These lipids also serve to activate enzyme systems that carry out complex reactions such as chromatin remodelling and pre-mRNA procesing. This issue of Current Topics in Microbiology and Immunology presents an overview of how phosphoinositides function in protein recruitment and enzyme activation and presents physiologically important examples of protein-phosphoinositide interactions.

Reviews

From the reviews:

"The book consists of seven chapters that focus on the various functions of PtdIns. … summarises recent advances in the burgeoning field of inositol lipids and provides a snapshot of where the field stands in 2003. The field is moving rapidly but this volume will be a useful addition for many researchers who have only recently discovered that their favourite protein is regulated by PtdIns." (Shamshad Cockcroft, nature cell biology, Vol. 6 (6), June, 2004)


Table of contents (7 chapters)

  • Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation

    Botelho, R. J. (et al.)

    Pages 1-30

  • Regulation of Endocytosis by Phosphatidylinositol 4,5-Bisphosphate and ENTH Proteins

    Itoh, T. (et al.)

    Pages 31-47

  • Membrane Targeting by Pleckstrin Homology Domains

    Cozier, G. E. (et al.)

    Pages 49-88

  • Protein Targeting to Endosomes and Phagosomes via FYVE and PX Domains

    Birkeland, H. C. G. (et al.)

    Pages 89-115

  • Regulation of the Actin Cytoskeleton by PI(4,5)P2 and PI(3,4,5)P3

    Hilpelä, P. (et al.)

    Pages 117-163

Buy this book

eBook $139.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-642-18805-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-540-00950-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-642-62299-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Phosphoinositides in Subcellular Targeting and Enzyme Activation
Editors
  • Harald Stenmark
Series Title
Current Topics in Microbiology and Immunology
Series Volume
282
Copyright
2004
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-18805-3
DOI
10.1007/978-3-642-18805-3
Hardcover ISBN
978-3-540-00950-4
Softcover ISBN
978-3-642-62299-1
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 209
Topics