Topics in Organometallic Chemistry

Organolithiums in Enantioselective Synthesis

Editors: Hodgson, David M. (Ed.)

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About this book

Organolithium chemistry occupies a central position in the selective construction of C-C bonds in both simple and complex molecules. Paralleling the surge of interest in methods for asymmetric synthesis, the use of organolithiums in enantioselective synthesis has witnessed spectacular advances in a little over a decade. This volume is the first dedicated to a comprehensive coverage of this important area. It is designed to provide graduate students and researchers with a rich source of essential information on synthesising molecules in an enantioselective manner using organolithiums, and be an inspiration for future developments. Following an overview chapter summarising the key milestones, successive chapters, each written by leading experts in their field, critically survey all the major areas of progress.

Reviews

This book is a valuable addition to the Topics in Organo-metallic
Chemistry series that has successfully culled a vast
topic into engaging and focused chapters through skillful
editorship. With minimal redundancy, the short text provides
comprehensive coverage of stereoselective deprotonations using
alkyllithiums in the presence of sparteine; the presentation
balances uninspiring examples with those in which the effectiveness
of the asymmetric depronation strategy is unsur-passed.

Interspersed throughout are complementary methods for
the creation and utilization of organolithiums in myriad reactions
that contribute meaningfully to the usefulness of the text. Clear
chapter headings and subject/author indexes make finding
information easy, and the volume will be a useful addition to
library reference collections.

Brian L. Pagenkopf, University of Texas at Austin

J. Am. Chem. Soc. 2003

To cover this very large subject, which has grown in size over several
decades and continues to develop rapidly, in such a compact form, as in this
volume, was certainly a demanding task, but it has been done successfully.
Through the sensible choice of topic areas and by the arrangement of the
material under different headings, the reader is given easy access to this complex subject.

Bernd Goldfuss
Institut für Organische Chemie
Universität Köln

Angewandte Chemie Int. Ed. 2004, 43, 778-781
www.angewandte.org
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

------

In this monograph, which is the newest addition to the excellent Topics in Organometallic Chemistry series, several authors from eight research groups around the world describe the current state of the art in the area of stereoselectivity control using organolithium reagents.
This book is a fine addition to any collection of synthetic monographs or to a library centering on organometallic reactions. Practitioners of stereoselective synthesis of natural products will likely find it very useful.

Marek Majewski
University of Saskatchewan, Canada

Adv. Synth. Catal. 2005, 347, 719-720
Wiley-VCH


Table of contents (9 chapters)

  • Overview of Organolithium-Ligand Combinations and Lithium Amides for Enantioselective Processes

    Hodgson, David M. (et al.)

    Pages 1-20

  • Enantioselective Addition of Organolithiums to C=O Groups and Ethers

    Goldfuss, Bernd

    Pages 21-36

  • Enantioselective Conjugate Addition and 1,2-Addition to C=N of Organolithium Reagents

    Iguchi, Mayu (et al.)

    Pages 37-59

  • Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Electrophile Incorporation

    Hoppe, Dieter (et al.)

    Pages 61-138

  • Enantioselective Synthesis by Lithiation Adjacent to Nitrogen and Electrophile Incorporation

    Beak, Peter (et al.)

    Pages 139-176

Buy this book

eBook $349.00
price for USA (gross)
  • ISBN 978-3-540-36117-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $489.00
price for USA
  • ISBN 978-3-540-00104-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $439.00
price for USA
  • ISBN 978-3-662-14612-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Organolithiums in Enantioselective Synthesis
Editors
  • David M. Hodgson
Series Title
Topics in Organometallic Chemistry
Series Volume
5
Copyright
2003
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-36117-6
DOI
10.1007/3-540-36117-0
Hardcover ISBN
978-3-540-00104-1
Softcover ISBN
978-3-662-14612-5
Series ISSN
1436-6002
Edition Number
1
Number of Pages
IX, 320
Topics