Overview
- Nominated as an outstanding Ph.D. thesis by the Duke University, USA
- Outlines the development of theranostic gold nanostars (GNS) for cancer diagnostics and therapy
- Analyzes in vivo the efficient combination of GNS nanoprobe with other imaging technologies
- Explores the biocompatibility of gold nanostars (GNS)
Part of the book series: Springer Theses (Springer Theses)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (7 chapters)
Keywords
- Multifunctional Nanoprobe
- Gold Nanostars (GNS)
- Nanomedicine
- Cancer Theranostics
- Cancer Imaging
- Cancer Immunotherapy
- Nanophotonics
- Surface Enhanced Raman spectroscopy (SERS)
- Photothermal Therapy (PTT)
- Two-photon photoluminescence (TPL)
- X-ray computer tomography (CT)
- Magnetic resonance imaging (MRI)
- Positron emission tomography (PET)
- Gold Nanostars biocompability
About this book
This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model.
Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer.The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.
Authors and Affiliations
About the author
Yang Liu obtained his bachelor’s (2007) and master’s degrees (2010) in Chemistry from Shanghai Jiao Tong University, China, where he studied molecular simulation in Dr. Huai Sun’s lab between 2005 and 2010. After coming to Duke University, USA in 2010, he developed a multifunctional gold nanoprobe for sensitive cancer imaging and phototherapy. He has won several awards including a “Kathleen Zielek” fellowship and “Student Travel Award” to the SPIE conference. He received his master’s degree in Biomedical Engineering in 2014 and Ph.D. degree in Chemistry in 2016 from Duke University. He is currently continuing his work on nanomedicine for cancer imaging and photoimmunotherpay as a postdoctoral research associate mentored by Dr. Tuan Vo-Dinh.
Bibliographic Information
Book Title: Multifunctional Gold Nanostars for Cancer Theranostics
Authors: Yang Liu
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-74920-4
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-74919-8Published: 23 March 2018
Softcover ISBN: 978-3-030-09104-0Published: 24 January 2019
eBook ISBN: 978-3-319-74920-4Published: 15 March 2018
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XX, 71
Number of Illustrations: 28 illustrations in colour
Topics: Nanochemistry, Cancer Research, Biomaterials, Spectroscopy/Spectrometry, Biomedical Engineering and Bioengineering, Medicinal Chemistry