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Targeting Trafficking in Drug Development

  • Book
  • © 2018

Overview

Editors:
  1. Alfredo Ulloa-Aguirre

    1. Red de Apoyo a la Investigación, National Autonomous University of Mexico and Instituto Nacional de Ciencias, Médicas y Nutrición SZ, Mexico City, Mexico

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    You can also search for this editor in PubMed   Google Scholar

  2. Ya-Xiong Tao

    1. Dep of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, Auburn, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Broadens your understanding of therapeutic intervention at the level of trafficking
  • Suitable for both experts needing information on recent advances and new researchers in the area
  • Written by leading authorities in the field of protein trafficking

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 245)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Intracellular Trafficking of Gonadotropin Receptors in Health and Disease

    • Alfredo Ulloa-Aguirre, Teresa Zariñán, Rubén Gutiérrez-Sagal, James A. Dias
    Pages 1-39

  3. Investigating Internalization and Intracellular Trafficking of GPCRs: New Techniques and Real-Time Experimental Approaches

    • Simon R. Foster, Hans Bräuner-Osborne
    Pages 41-61

  4. Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors

    • Bernard Mouillac, Christiane Mendre
    Pages 63-83

  5. Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases

    • Francesca Longhena, PierFranco Spano, Arianna Bellucci
    Pages 85-110

  6. Pharmacoperones for Misfolded Gonadotropin Receptors

    • Claire L. Newton, Ross C. Anderson
    Pages 111-134

  7. Pharmacological Chaperones: Beyond Conformational Disorders

    • Nancy J. Leidenheimer
    Pages 135-153

  8. Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer

    • Isabel Betancor-Fernández, David J. Timson, Eduardo Salido, Angel L. Pey
    Pages 155-190

  9. Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches

    • Meritxell B. Cutrona, Niamh E. Morgan, Jeremy C. Simpson
    Pages 191-225

  10. Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking

    • Leslie K. Climer, Rachel D. Hendrix, Vladimir V. Lupashin
    Pages 227-247

  11. SLC6 Transporter Folding Diseases and Pharmacochaperoning

    • Michael Freissmuth, Thomas Stockner, Sonja Sucic
    Pages 249-270

  12. The Molecular Physiopathogenesis of Islet Amyloidosis

    • Diti Chatterjee Bhowmick, Sanghamitra Singh, Saurabh Trikha, Aleksandar M. Jeremic
    Pages 271-312

  13. Folding Defects Leading to Primary Hyperoxaluria

    • Elisa Oppici, Mirco Dindo, Carolina Conter, Carla Borri Voltattorni, Barbara Cellini
    Pages 313-343

  14. Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria

    • Tomas Majtan, Angel L. Pey, Paula Gimenez-Mascarell, Luis Alfonso Martínez-Cruz, Csaba Szabo, Viktor Kožich et al.
    Pages 345-383

  15. Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator and Drugs: Insights from Cellular Trafficking

    • Robert J. Bridges, Neil A. Bradbury
    Pages 385-425
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Keywords

About this book

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

Editors and Affiliations

  • Red de Apoyo a la Investigación, National Autonomous University of Mexico and Instituto Nacional de Ciencias, Médicas y Nutrición SZ, Mexico City, Mexico

    Alfredo Ulloa-Aguirre

  • Dep of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, Auburn, USA

    Ya-Xiong Tao

Bibliographic Information

  • Book Title: Targeting Trafficking in Drug Development

  • Editors: Alfredo Ulloa-Aguirre, Ya-Xiong Tao

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-319-74164-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-74163-5Published: 27 April 2018

  • Softcover ISBN: 978-3-030-08927-6Published: 15 February 2019

  • eBook ISBN: 978-3-319-74164-2Published: 18 April 2018

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VIII, 425

  • Number of Illustrations: 2 b/w illustrations, 55 illustrations in colour

  • Topics: Pharmacology/Toxicology, Cell Biology

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