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Heat Shock Proteins in the Immune System

  • Book
  • © 2018

Overview

Editors:
  1. Robert J. Binder

    1. Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

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  2. Pramod K. Srivastava

    1. Carole and Ray Neag Comprehensive Cancer Center and the Department of Immunology, University of Connecticut School of Medicine, Farmington, USA

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  • Comprehensive resource on the immunobiology of HSPs

  • One-stop resource on HSPs for both immunologists and cancer researchers

  • Numerous illustrations aid in clarifying HSPs to both experts and non-experts

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-x
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  2. Structure of the HSPs in Relation to Chaperoning Peptides and Proteins

    1. Front Matter

      Pages 1-1
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    2. Hsp70-Substrate Interactions

      • Roman Kityk, Matthias P. Mayer
      Pages 3-20

    3. Molecular Chaperone Inhibitors

      • Michael A. Moses, Abbey D. Zuehlke, Len Neckers
      Pages 21-40

  3. Exposure of HSPs to Immune Cells

    1. Front Matter

      Pages 41-41
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    2. Extracellular Heat Shock Proteins as Stress Communication Signals

      • Antonio De Maio
      Pages 43-59

  4. Regulation of Immune Responses by Extracellular HSPs

    1. Front Matter

      Pages 61-61
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    2. The Heat Shock Protein-CD91 Pathway and Tumor Immunosurveillance

      • Robert J. Binder
      Pages 63-73

    3. Bridging the Gaps in the Vaccine Development: Avant-Garde Vaccine Approach with Secreted Heat Shock Protein gp96-Ig

      • Natasa Strbo
      Pages 75-95

    4. Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones

      • Natasha Marie-Eraine Boel, Adrienne Lesley Edkins
      Pages 97-121

    5. Roles, Mechanisms, and Opportunities of Heat Shock Protein gp96/grp94 in Infections and Inflammation-Associated Malignancies

      • Songdong Meng, Zihai Li
      Pages 123-140

    6. An Ancestral Immune Surveillance System in the Amphibian Xenopus Connecting Certain Heat Shock Proteins with Classical and Nonclassical MHC Class I Molecules

      • Jacques Robert, Maureen Banach, Eva-Stina Edholm
      Pages 141-155

    7. Inhibition of HSPs for Enhanced Immunity

      • Ronald J. Fecek, Subhara Raveendran, Manoj Chelvanambi, Walter J. Storkus
      Pages 157-180

  5. Back Matter

    Pages 181-185
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Keywords

About this book

Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.  

Editors and Affiliations

  • Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

    Robert J. Binder

  • Carole and Ray Neag Comprehensive Cancer Center and the Department of Immunology, University of Connecticut School of Medicine, Farmington, USA

    Pramod K. Srivastava

About the editors

Pramod K. Srivastava, Department of Immunology, University of Connecticut Health Center
Robert J. Binder, Department of Immunology, University of Pittsburgh

Bibliographic Information

  • Book Title: Heat Shock Proteins in the Immune System

  • Editors: Robert J. Binder, Pramod K. Srivastava

  • DOI: https://doi.org/10.1007/978-3-319-69042-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-69040-7Published: 18 April 2018

  • Softcover ISBN: 978-3-030-09862-9Published: 28 December 2018

  • eBook ISBN: 978-3-319-69042-1Published: 09 April 2018

  • Edition Number: 1

  • Number of Pages: X, 185

  • Number of Illustrations: 2 b/w illustrations, 20 illustrations in colour

  • Topics: Immunology, Protein Science, Infectious Diseases, Cancer Research

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