Overview
- Addresses all aspects of the molecular and cellular biology of extracellular and intracellular immune checkpoint regulators
- Promotes the understanding and application of extended immune checkpoint regulators
- Offers new strategies for the therapy of various diseases, such as autoimmune diseases and cancer
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 410)
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Table of contents (11 chapters)
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Front Matter
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Extracellular Immune Checkpoint Molecules
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Front Matter
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Keywords
About this book
This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.
Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
Editors and Affiliations
About the editor
Akihiko Yoshimura, PhD
Department of Microbiology and Immunology,
Keio University School of Medicine
35 Shinanomachi, Shinjyuku-ku, Tokyo
160-8582, Japan
Phone: +81-3-5363-3483
FAX: +81-3-5360-1508
yoshimura@a6.keio.jp
Bibliographic Information
Book Title: Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity
Editors: Akihiko Yoshimura
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-68929-6
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017
Hardcover ISBN: 978-3-319-68928-9Published: 13 December 2017
Softcover ISBN: 978-3-319-88684-8Published: 04 September 2018
eBook ISBN: 978-3-319-68929-6Published: 25 November 2017
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VIII, 267
Topics: Immunology, Cancer Research, Cell Biology