Inflammation and Angiogenesis

1. Front Matter

   Pages i-viii

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2. Introduction

   • Domenico Ribatti

   Pages 1-7

3. The Importance of Microenvironment in Tumor Metastasis

   • Domenico Ribatti

   Pages 9-11

4. Immune Cells

   • Domenico Ribatti

   Pages 13-14

5. Lymphocyte Homing

   • Domenico Ribatti

   Pages 15-16

6. Inflammation and Cancer

   • Domenico Ribatti

   Pages 17-24

7. Inflammation and Angiogenesis

   • Domenico Ribatti

   Pages 25-26

8. The Contribution of Immune Cells to Angiogenesis in Inflammation and Tumor Growth

   • Domenico Ribatti

   Pages 27-84

9. Conclusions

   • Domenico Ribatti

   Pages 85-86

10. Back Matter

    Pages 87-111

    PDF

This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter. 

• Inflammation
• Angiogenesis
• Immnune cells
• tumor growth
• Cancer

• Department of Biomedical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy

  Domenico Ribatti

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