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Advances in Experimental Medicine and Biology

Understanding the Gut-Bone Signaling Axis

Mechanisms and Therapeutic Implications

Editors: McCabe, Laura R., Parameswaran, Narayanan (Eds.)

  • The first book  to combine current knowledge on gut and bone research
  • Authored by international experts in the field
  • Reviews exhaustively the key recent research regarding everything from signaling pathways to pathologies to intestinal environments
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Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-66653-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-66651-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area.  The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area.

About the authors

Laura R. McCabe, PhD is the Director of the Molecular Metabolism and Disease Program at Michigan State University. Dr. McCabe’s research focuses on understanding the mechanisms regulating bone cell (osteoblast) differentiation and bone formation. Her lab is taking an integrative approach to examine bone adaptation to diseases (such as diabetes and inflammatory bowel disease) and is working toward identifying mechanisms regulating bone formation by osteoblasts.  Approaches include examination of transcription factor activity, intracellular signaling pathway activation, stem cell lineage selection, apoptosis, metabolism and immune system contributions utilizing cell culture systems, animal models and human imaging. Dr. McCabe’s lab is also developing therapeutics to target identified mechanisms and pathways to increase bone formation.

Table of contents (6 chapters)

  • Stomach and Bone

    Alice M. Kitay, John P. Geibel

    Pages

  • Prebiotics and Bone

    Corrie M. Whisner, Connie M. Weaver

    Pages

  • Intestinal Incretins and the Regulation of Bone Physiology

    Walter Ramsey, Carlos M. Isales MD

    Pages

  • Epithelial Barrier Function in Gut-Bone Signaling

    Naiomy Deliz Rios-Arce, et al.

    Pages

  • Regulation of Bone Metabolism by Serotonin

    Brigitte Lavoie, Jane B. Lian, Gary M. Mawe

    Pages

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-3-319-66653-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-3-319-66651-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Understanding the Gut-Bone Signaling Axis
Book Subtitle
Mechanisms and Therapeutic Implications
Editors
  • Laura R. McCabe
  • Narayanan Parameswaran
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1033
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-66653-2
DOI
10.1007/978-3-319-66653-2
Hardcover ISBN
978-3-319-66651-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIII, 277
Number of Illustrations and Tables
7 b/w illustrations, 29 illustrations in colour
Topics