Overview
An up-to-date account of supramolecular ligands
Essential reading for academic and industrial scientists interested in drug targeting
A comprehensive overview of the enhancement of immune complexation
Buy print copy
Tax calculation will be finalised at checkout
Table of contents (8 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. This book is an open access under a CC BY license.
Editors and Affiliations
About the editors
Dr Irena Roterman-Konieczna – professor of bioinformatics heads the bioinformatics group at the Jagiellonian University – Medical College and the Faculty of Physics, Astronomy and Applied Computer Science, Poland. Her background is the theoretical chemistry and her research focuses on bioinformatics with a special focus on protein structure prediction. Involved also in education of medical students and students of computer science developing different forms of simulations in medicine.
Bibliographic Information
Book Title: Self-Assembled Molecules – New Kind of Protein Ligands
Book Subtitle: Supramolecular Ligands
Editors: Irena Roterman, Leszek Konieczny
DOI: https://doi.org/10.1007/978-3-319-65639-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s) 2018
License: CC BY
Hardcover ISBN: 978-3-319-65638-0Published: 23 November 2017
Softcover ISBN: 978-3-319-88071-6Published: 11 September 2018
eBook ISBN: 978-3-319-65639-7Published: 03 November 2017
Edition Number: 1
Number of Pages: XII, 136
Number of Illustrations: 54 b/w illustrations, 44 illustrations in colour
Topics: Biomedicine general, Protein Science, Protein-Ligand Interactions, Biological Techniques