Springer Theses

A Network-Based Approach to Cell Metabolism

From Structure to Flux Balances

Authors: Güell, Oriol

  • Nominated as an outstanding Ph.D. thesis by the University of Barcelona, Spain
  • Unveils new mechanisms and responses impossible to demonstrate with by traditional reductionist procedures
  • Has given rise to a large number of articles in scholarly journals
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eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-64000-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-63999-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.

The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.

Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec

ts of the networks themselves to the balance of biochemical fluxes.

 

About the authors

Oriol Güell holds a Ph.D. in Physical Chemistry from the University of Barcelona, Spain, and has broad experience in the theoretical modelling and the experimental applications of magnetic colloidal dispersions and in the computer modelling of metabolic networks. Currently, his main research focuses on obtaining and applying bio-based polymers and plasticisers and studying their associated physicochemical properties.

Table of contents (7 chapters)

  • Cellular Metabolism at the Systems Level

    Güell, Oriol

    Pages 1-24

  • Methods and Data

    Güell, Oriol

    Pages 25-52

  • Structural Knockout Cascades in Metabolic Networks

    Güell, Oriol

    Pages 53-76

  • Effects of Reaction Knockouts on Steady States of Metabolism

    Güell, Oriol

    Pages 77-100

  • Detection of Evolution and Adaptation Fingerprints in Metabolic Networks

    Güell, Oriol

    Pages 101-113

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-3-319-64000-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $129.00
price for USA
  • ISBN 978-3-319-63999-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
A Network-Based Approach to Cell Metabolism
Book Subtitle
From Structure to Flux Balances
Authors
Series Title
Springer Theses
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-64000-6
DOI
10.1007/978-3-319-64000-6
Hardcover ISBN
978-3-319-63999-4
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XX, 151
Number of Illustrations and Tables
49 b/w illustrations
Topics